Antithrombotic Drugs

Question 1

What are the antiplatelet drugs?

Answer 1

Aspirin
Clopidogrel and Prasugrel
Dipyridamole and Cilostazol
Abciximab, eptifibatide, and tirofiban

Question 2

What is the mechanism of action of aspirin?

Answer 2

Irreversibly inhibits the enzyme cyclooxygenase (COX) which blocks thromboxane A2

Question 3

What is the mechanism of action of clopidogrel and prasugrel?

Answer 3

Inhibits the binding of ADP to its platelet P2Y12 receptor

Question 4

What is the mechanism of action of abciximab, eptifibatide and tirofiban?

Answer 4

Blocks binding of fibrinogen to glycoprotein IIb/ IIIa receptors on the platelet which inhibit platelet aggravation

Question 5

What is the mechanism of action of warfarin?

Answer 5

Inhibits vitamin K dependant clotting factors - II, VII, IX and X
Anticoagulant

Question 6

What is the mechanism of action of heparin?

Answer 6

Binds reversibly to ATIII leads to inactivation factors IIa and Xa
Factor Xa cleaves prothrombin to make thrombin

Question 7

What is the mechanism of action of apixaban, edoxaban and rivaroxaban?

Answer 7

Direct and reversible inhibitors of factor Xa which prevents thrombin generation
Anticoagulant

Question 8

What is the mechanism of action of Dabigatran and Bivalirudin/ Argatroban?

Answer 8

Reversible inhibitor of free thrombin, fibrin bound thrombin, and thrombin-induced platelet aggregation