Antiseizure Medications Flashcards
What is an antiepileptic?
Used to control or prevent seizures. The specific drug therapy is based on the type and frequency of the seizures.
What is the generic name for Dilantin?
phenytoin
What types of seizures does Dilantin treat?
- Simple seizures
- Complex seizures
- Partial seizures
- Generalized tonic clonic seizures
What are the effects of Dilantin on EEG?
Mild slowing
What are the toxic levels of Dilantin indicated by on EEG?
Generalized delta
What is the generic name for Phenobarbital?
Barbita, luminal, solfolon
What seizure types does Phenobarbital treat?
- Most seizure types
- Febrile seizures
- Status epilepticus
- Partial complex when others fail
What are the effects of Phenobarbital on EEG?
- Generalized anterior dominant fast 15-35 Hz
- Posterior fast (children)
What is the generic name for Tegretol?
carbamazepine
What types of seizures does Tegretol treat?
Partial and generalized tonic clonic seizures
What are the effects of Tegretol on EEG?
- None
- Mild alpha slowing
- Increased beta
What is the generic name for Trileptal?
oxcarbazepine
What types of seizures does Trileptal treat?
Partial seizures
What are the effects of Trileptal on EEG?
- Slowing of peak frequency
- Increased theta & delta
What is the generic name for Neurontin?
gabapentin
What types of seizures does Neurontin treat?
Partial and secondary generalized seizures
What are the effects of Neurontin on EEG?
- Minimally increase delta & theta
- Decreased alpha
What is the generic name for Lyrica?
pregabalin
What types of seizures does Lyrica treat?
Partial seizures
What is the generic name for Zarontin?
ethosuximide
What type of seizures does Zarontin treat?
Absence seizures
What is the generic name for Vimpat?
lacosamide
What types of seizures does Vimpat treat?
Partial and secondary generalized seizures
What is the generic name for Sabril?
vigabatrin
What is the generic name for Lamictal?
Lamotrigine
What is Lamictal used for?
Used as an adjustment for partial seizures
What are the effects of Lamictal on EEG?
- None
- Increases interictal spikes in photoparoxysmal responses
What is the generic name for Topomax?
Topiramate
What is the generic name for Keppra?
Levetiracetam
What types of seizures does Keppra treat?
- Partial seizures
- Generalized tonic clonic seizures
What is the generic name for Klonopin?
Clonazepam
What types of seizures does Klonopin treat?
- Absence seizures
- Myoclonic seizures
- Atonic seizures
- Lennox-Gastaut syndrome
What are the effects of Klonopin on EEG?
- Loss of background
- Decreased voltage
- Frontal beta, some theta
What is the generic name for Banzel?
rufinamide
What types of seizures does Banzel treat?
- Lennox-Gastaut associated seizures
- Absence seizures
- Myoclonic seizures
- Atonic seizures
What is the generic name for Ativan?
Lorazepam
What is Ativan used for?
Short term treatment of all seizures, status epilepticus, and generalized tonic clonic seizures
What are the effects of Ativan on EEG?
- Loss of background
- Decreased voltage
- Frontal beta, some theta
What is the generic name for Felbatol?
Felbamate
What types of seizures does Felbatol treat?
- Seizures when all other medication fails
- Partial seizures
- Some generalized seizures
- Lennox-Gastaut associated seizures
What are the effects of Felbatol on EEG?
None
What is the generic name for Mysoline?
Primidone
What types of seizures does Mysoline treat?
- Focal seizures
- Generalized tonic clonic seizures
- Myoclonic seizures
What are the effects of Mysoline on EEG?
- Increased fast activity, frontally predominant
- Decreased alpha
What is the generic name for Valium?
Diazepam
What is Valium used for?
Short term treatment of all seizures, status epilepticus
What are the effects of Valium on EEG?
Frontally predominant fast activity but can be more diffuse
What is the generic name for Gabitril?
Tiagabine
What types of seizures does Gabitril treat?
Partial and some generalized seizures
What are the effects of Gabitril on EEG?
None
What is the generic name for Haldol?
Haloperidol
What conditions does Haldol treat?
- Schizophrenia
- Tourettes Syndrome
- Tremors
- Huntington’s chorea
What are the effects of Haldol on EEG?
Paradoxical effects, slow and fast activity
What is the generic name for Librium?
Chlordiazepoxide HCL
What is Librium used for?
Tranquilizer
What are the effects of Librium on EEG?
Anterior dominant diffuse fast
What is the generic name for Demerol?
Meperidine
What is Demerol used for?
Analgesic (pain relief)
What are the effects of Demerol on EEG?
- Slowing of alpha
- Generalized slowing
What is the generic name for Morphine?
Morphine
What is Morphine used for?
Analgesic (severe pain relief)
What are the effects of Morphine on EEG?
- Acute dosage: decrease in frequency and amount of alpha
- Chronic dosage: alpha returns to normal and increase in amount
- Toxic dosage: diffuse slowing
What is the generic name for Codeine?
Codeine
What is Codeine used for?
Analgesic (pain and cough relief)
What are the effects of Codeine on EEG?
- Decrease in frequency and amount of alpha
- Chronic dosage: alpha returns to normal
What is the generic name for ACTH?
Adrenocorticotropic hormone
What is ACTH used for?
Treatment for all cerebral edema with brain tumors and infantile spasms
What are the effects of ACTH on EEG?
No appreciable effect
What is the generic name for Amytal?
Sodium amytal
What is Amytal used for?
Wada testing
What are the effects of Amytal on EEG?
Enhanced beta
What is the generic name for Chloral hydrate?
Chloral hydrate
What are the effects of Chloral hydrate on EEG?
Little to no effect, increased anterior dominant beta
Pentobarbital can cause what EEG pattern?
Burst suppression, beta activity
A bolus of propofol results in
Burst suppression
What medication is used to treat West Syndrome?
Vigabatrin
What treatment is available for patients with Otahara Syndrome?
Focal resection, cerebral hemispherectomy, Ketogenic diet, ACTH injections, anti-seizure medications, VNS
What AED is recommended for West Syndrome?
Vigabatrin
Rapid removal of which anticonvulsant is most likely to cause a generalized seizure?
Phenobarbital
What is the surgical treatment for Sturge Weber’s?
Hemispherectomy
What is the first line treatment for Lennox-Gastaut Syndrome?
Valproic acid
Total suppression of the EEG followed by cardiovascular instability can be caused by:
Barbiturates
What treatment is used for partial seizures?
Vagus nerve stimulation
What is the safest AED for pregnant women?
Lamictal
What surgical procedure is used to treat Hypothalamic Harmartomas?
Gamma knife
What are the AED options for absence seizures?
Valproic acid and Ethosuximide
What AED options are available for atypical absence, myoclonic, and atonic seizures?
Valproic acid, Lamotrigine, and Topiramate
What are the AED options for focal aware/impaired awareness seizures?
Carbamazepine, Phenytoin, Oxcarbazepine, Valproic acid
What are the AED options for primary generalized seizures with TC movements?
Valproic acid, Lamotrigine, Topiramate
What is the treatment for Angelman’s Syndrome?
Valproate to reduce seizures, no known surgical treatment
What AED is used for the treatment of childhood occipital spikes?
Carbamazepine
What is the AED for Dravet Syndrome?
Valproate, Clobazam
What is the surgical treatment for drop attacks?
Corpus Callostomy
What is the AED for Early Myoclonic Encephalopathy?
Clobazam, Clonazepam
What is the AED for Jaevon’s syndrome?
Levetiracetam
What is the AED for epilepsy with myoclonic absence?
Valproic acid, Lamotrigine, Topiramate
What is the AED for epilepsy with myoclonic-atonic seizures?
Valproate
What AED can be used to treat electrical status epilepticus of sleep (ESES)?
Diazepam
What AED can be used to treat febrile seizures?
Diazepam as rescue only
What AED is used for hyperkinetic frontal lobe?
Carbamazepine
What type of changes would you expect to see on an EEG from a patient on Haldol?
Paradoxical effects, slow and fast activity
What is another name for Phenobarbital?
Luminal
What is another name for Dilantin?
Phenytoin
What is another name for Chlorpromazine?
Thorazine
What is another name for Codeine?
Acetaminophen
What is another name for Librium?
Chlordiazepoxide
What is another name for Haloperidol lactate?
Haldol
What is another name for Gabitril?
Tiagabine
What is another name for Valium?
Diazepam
What is another name for Mysoline?
Primidone
What is another name for Felbatol?
Felbamate
What is another name for Ativan?
Lorazepam
What is another name for Banzel?
Rufinamide
What is another name for Klonopin?
Clonazepam
What is another name for Keppra?
Levetiracetam
What is another name for Zonegran?
Zonisamide
What is another name for Topamax?
Topiramate
What is another name for Lamictal?
Lamotrigine
What is another name for Depakene?
Valproic acid
What is another name for Sabril?
Vigabatrin
What is another name for Vimpat?
Lacosamide
What is another name for Zarontin?
Ethosuximide
What is another name for Lyrica?
Pregabalin
What is another name for Neurontin?
Gabapentin
What is another name for Trileptal?
Oxycarbazepine
What is another name for Tegretol?
Carbamazepine