Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CVS-PHARMA > Antirrhythmatics Drugs > Flashcards

Antirrhythmatics Drugs Flashcards

1
Q

Class IA drugs function?

A

Prolong the refractory period
Slows the conduction
Or slows the phase 0 depolarisation of the ventricle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the names of class IA anti arrhythmics?

A

Quinidine
Disopyramide
Procainamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Class IA drugs are used to suppress ________________

A

Ventricular arrhythmias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Quinidine is used for ventricular and supraventricular arrhythmia especially caused by ________

A

Ectopia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the uses of quinidine

A

Ventricular and supraventricular arrhythmia

Maintain sinus rhythm after conversion of atrial flutter or fibrillation by drugs

Quinine isomer so antimalarial antipyeritic and oxytoxic effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are adverse effects of quinidine

A 
Skeletal muscle weakness (especially in myasthenia gravis)
Hypotension and shock
Cinchonism
Thrombocytopenia
Quinidine syncope
GI distress
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is quinidine syncope

A

Dizziness and fainting due to ventricular tachycardia. Associated with a prolonged QT interval

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Quinidine increases the plasma levels of ___________ and risk of _________ toxicity

A

Digoxin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Quinidine causes _________ toxicity

A

Digoxin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Digoxin toxicity is due to __________ class IA anti arrhythmic

A

Quinidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The t1/2 of quinidine is decreased by?

A

Phenytoin and phenobarbital

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

The cardiotoxic effects of quinidine are exacerbated by ______________

A

Hyperkalemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Lupus like syndrome is a consequence of _____________

A

Procainamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Procainamide pros?

A

Safer to use as IV

Few GI adverse effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Procainamide cons?

A

Lupus like syndrome
Dose reduction in renal failure
Severe of irreversible heart failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Onset of Lupus like syndrome is early in ________ acetylators (slow/fast)

A

Slow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Procainamide is acetylated to__________ that also has anti arrhythmic properties

A

NAPA(n-acetyl provainamide)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Half life of procainamide?

A

3-4 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Disopyramide has the _________ (shortest/longest) half life of its class

A

Longest

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Disopyramide is used for the treatment of ventricular arrhythmias generally for ____________

A

Cases refractory or intolerant to quinidine or procainamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Adverse effects of disopyramide

A 
Dry mouth
Blurred vision
Constipation
Urinary retention
Acute angle closure glaucoma
Worsen heart block and adversely affect sinus node function
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

_________is the second line choice for the treatment pf ventricular arrhythmias

A

Lidocaine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

First line choice for treating ventricular arrhythmias?

A

Amiodarone

Electrical defibrillation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

____________ is ineffective in the prevention of arrhythmia subsequent to MI

A

Lidocaine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Dose of lidocaine has to be adjusted in _________ and _________

A

CHF

Hepatic disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Adverse effects of lidocaine?

A

Neurological symptoms like seizures

Low toxic effect on heart and autonomic nervous system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

____________ used for the long term tx of ventricular arrhythmia associated with previous MI (class IB)

A

Mexiletine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Flecainide is used for?

A

Maintenance of sinus rhythm in pts w/ paroxysmal atrial fibrillation or atrial flutter
Ventricular tachyarrhythmias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

What does class IC drugs do?

A

Maximally slows the rate of phase 0 depolarization of ventricles
Slows His-perkunjie conduction
Causes QRS widening
Shorten the action potential of perkunjie fibers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Class IC drugs use is limited due to _________

A

proarrhythmias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Use flecainide w/ caution in patients w/ ________, __________ and ____________

A

CHF
Post MI
Sinus node dysfunction (SND)

32
Q

Propafenone is a class _____ drug

A

Class IC

33
Q

Propafenone is used for?

A

Supraventricular arrhythmias

Ventricular arrhythmias

34
Q

Adverse effects of propafenone?

A

CHF
Bradycardia
New arrhythmias

35
Q

What are the names of class II antiarrhythmic drugs?

A

Propranolol
Esmolol
Acebutalol

36
Q

WHat are the functions of class II drugs?

A

Decrease automaticity
Slows HR and contractility
Prolongs the AV nodal conduction
Inhibit phase 4 depolarization

37
Q

What are class II drugs?

A

Beta antagonist

38
Q

Group the class II drugs acc to selective and non selective B antagonist?

A

B1 selective - Esmolol and Acebutalol

B nonselective - Propranolol

39
Q

Class II drugs are used for the treatment of ventricular tachyarrhythmias due to ___________

A

increased sympathetic activity

40
Q

What is propranolol used for?

A

Atrial fibrillation/flutter
Reflex tachycardia due to vasodilating agents
Digitalis toxicity
Recurrent MI

41
Q

What are the adverse effects of propranolol?

A 
Bronchospasm (don't give in asthma)
Arteriolar vasoconstriction
Myocardial depression
Bradycardia
Heart block
42
Q

__________ and __________ are given for the adverse effects of propranolol? (bradycardia)

A

Atropine and Isoproterenol

43
Q

What are the names of class III drugs?

A 
Amiodarone
Dronedarone
Sotalol
Ibutilide
Dufetilide
44
Q

Amiodarone → uses?

A

Ventricular arrhythmias in preference to lidocaine
Conversion of Atrial fibrillation
Suppression of arrhythmias in pts w/ implanted defibrillators
Antianginal and vasodilatory effects

45
Q

_________ is the first line agent for patients refractory to CPR

A

Amiodarone

46
Q

Dronedarone is used for the treatment of _____________

A

permanent atrial fibrillation/flutter (that cannot be converted to normal sinus rhythm)

47
Q

Amiodarone has a ________ half life

A

long (14-100 days)

so effects take a long time to set in and stays for long period

48
Q

Amiodarone has long half life so it can be used for patients who have _________

A

long working hours

49
Q

What r the adverse effects of amiodarone?

A 
Gray man syndrome
Pulmonary fibrosis
Interstitial pneumonitis
GI related effects
Photosensitivity
Corneal microdeposits
Thyroid disorders
50
Q

Amidarone is structurally related to ________-

A

thyroxine

51
Q

Defutilide and Ibutilide are used for ___________

A

maintanence of sinus rhythm after conversion of atrial fibrillation/flutter

52
Q

___________ does not affect the conduction velocity (Class III)

A

Defutilide

53
Q

What is the function of class III drug?

A

Prolongs the action potential duration and effective refractory period

54
Q

__________ also has B-adrenoceptor antagonist activity (class III)

A

sotalol

55
Q

Adverse effects of Sotalol?

A

Proarrhythmias
Dyspnea
Dizziness

56
Q

What are the name sof class IV drugs?

A

Verapamil

Diltiazem

57
Q

Class IV drugs block ______________-

A

L type Ca channels

58
Q

Class IV drugs functions?

A

Prolong nodal conduction and effective refractory period

59
Q

Effect of Class IV drugs is mainly on the ________

A

node

60
Q

Dose reduction is required in ________ and __________ in verapamil

A

hepatic disease

elderly

61
Q

What is verapamil used for?

A

Reentrant supraventricular tachycardia

Reduce ventricular rate in atrial flutter/fibrillation

62
Q

Verapamil has _______ inotropic effect

A

negative

63
Q

Verapamil can lead to ________ if given in large doses or in patients w/ partial blockage

A

AV block

64
Q

Verapamil adverse effects

A 
Sinus bradycardia
Sinus arrest
Peripheral vasodilation
Transient asystole
Arrhythmias
65
Q

Arrhythmias due to verapamil can get exacerbated due to ____________

A

B adrenoceptor antagonists

66
Q

Arrhythmias due to verapamil and B antagonists can be reversed by?

A

Atropine
B agonists
Calcium

67
Q

Verapamil should not be used in patients w/ abnormal conduction circuits like in ____________-

A

Wolff-Parkinson white syndrome

68
Q

What is the advantage of diltiazem over verapamil?

A

Diltiazem has less inotropic effect

69
Q

Uses of diltiazem

A

Supraventricular arrhythmias because of inhibitory effects on conduction through AV node

70
Q

How does adenosine works?

A

Acts thru purinergic receptors
Increase K+ influx and decrease Ca++ influx leading to hyperpolarization and decreases calcium dependent part of action potential

71
Q

Adenosine is the DRUG OF CHOICE for the tx of __________________ including those associated w/ Wolff parkinson white syndrome

A

Paroxysmal supraventricular arrhythmias

72
Q

Digoxin controls the __________ response in atrial flutter/fibrillation

A

ventricular response

73
Q

__________ is used for the treatment of bradycardia that accompany MI

A

Atropine

74
Q

Isoproterenol is used to _____________ and ____________ in patients w/ AV block

A

maintain heart rate

cardiac output

75
Q

Adverse effects of Isoproterenol?

A 
Tachycardia
Anginal effects
Headache
Dizziness
Flushing
Tremors

CVS-PHARMA (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions