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Psych > Antipsychotics and Anticholinergics > Flashcards

Antipsychotics and Anticholinergics Flashcards

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1
Q

Haloperidol Classification

A

1st Gen Antipsychotics

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2
Q

Haloperidol Therapeutic Effect

A

dopamine antagonist - emotional quieting

tx only positive symptoms of Schizophrenia (hallucinations/delusions)

⬇️ Norepinephrine - mania, anxiety, aggression

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3
Q

Haloperidol Side Effects / Adverse Effects

A

EPSEs - Extrapyramidal SE

Amenorrhea, galactorrhea (women), gynecomastea (men) from blockade of dopamine with increased prolactin

Blurred vision, dry mouth, urinary hestitancy, constipation from blockade of acetylcholine

Orthostatic hypotension from blockade of muscarinic receptors

Weight gain and sedation from blockade of histamine

Neuroleptic malignant syndrome - decreased consciousness and responsiveness, increased muscle tone and autonomic dysfunction caused by excessive dopamine receptor blockade. Fatal in 10% of cases

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4
Q
A
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5
Q

Clozapine Classification

A

2nd Gen Antipsychotics (SGA)

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6
Q

Clozapine Therapeutic Effect

A

Emotional quieting (blocked dopamine)
Improved mood (increase serotonin)
Tx + and - symptoms of schizophrenia

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7
Q

Clozapine
Side Effects

A

Bone marrow suppression
Agranulocytosis
Can be fatal

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8
Q

Risperidone

A

2nd Gen Antipsychotics (SGA)

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9
Q

Paliperidone

A

2nd Gen Antipsychotics (SGA)

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10
Q

Quetiapine

A

2nd Gen Antipsychotics (SGA)

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11
Q

Olanzapine

A

2nd Gen Antipsychotics (SGA)

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12
Q

Ziprasidone

A

2nd Gen Antipsychotics (SGA)

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13
Q

Aripiprazole

A

2nd Gen Antipsychotics (SGA)

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14
Q

Benztropine

A

Anticholinergic

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15
Q

CRAPiZgOzQs

2nd Gen Antipsychotics

A

CLOZapine
RISPERidone
Aripiprazole
Paliperidone

Ziprasidone
Olanzapine
Quetiapine

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16
Q

2nd Gen SE

A

Fewer EPSEs

Metabolic syndrome - weight gain, hyperglycemia/insulin resistance, triglycerides

Sexual dysfunction

NMS

17
Q

Risperidone SEs

A

Highest risk for EPSEs
⏫ Prolactin
Orthostatic hypotension
Wt gain
Sedation
Sexual dysfunction

18
Q

Paliperidone SEs

A

similar to Risperidone

19
Q

Quetiapine SEs

A

Strong sedation and wt gain

20
Q

Olanzapine SEs

A

Highest SGA risk for metabolic syndrome, highly sedating (street value for this)

21
Q

Ziprasidone SEs

A

Prolongs QT interval, used for emergencies

22
Q

Aripiprazole SEs

A

Insomnia, akathisia, low risk for metabolic syndrome, wt neutral and less hyperprolactinemia and sedation

23
Q

Benztropine (anticholinergic) SEs

A

Dry mouth
Blurred vision
Constipation
Urinary retention
Orthostatic hypotension

24
Q

Benztropine (anticholinergic) Use

A

Preventative or acute tx of EPSEs (dystonia) - restores natural balance of acetylcholine and dopamine

Psych (4 decks)

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