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antipsychotics > antipsychotics > Flashcards

antipsychotics Flashcards

1
Q

low potency typical antipsychotics list

A

chlorpromazine

thioridazine

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2
Q

high potency typical antipsychotics list

A

haloperidol

fluphenazine

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3
Q

atypical antipsychotics group 1 list

A 
Olanzapine
risperidone 
paliperidone, 
iloperidone
quetiapine, 
clozapine
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4
Q

atypical antipsychotics group 2 list

A

ziprasaidone
aripiprazole
lurasidone

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5
Q

more atypical antipsychotics list

A

asenapine
iloperidone
brexpiprazole
cariprazine

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6
Q

mood stabilizer antiseizure drug list

A

valproate
lamotrigine
carbamazepine
lithium

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7
Q

chlorpromazine

A 
lots of sedation
and adverse effects 
hold back neurological processing 
good for positive symptoms 
bad because movement disorder
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8
Q

thioridazine

A

extensive 1st pass metabolist
good for positive symptoms
bad because cardiotoxicity and retinopathy

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9
Q

haloperidol use

A

initial antipsychotic for rapid onset in acute psychosis
also maintenance therapy for pts refractory to other antipsychotics
Strong D2 receptor inhibitor

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10
Q

side effects of haloperidol

A

extrapyramidal toxicity
very little hypotension
low rates of metabolic effects
low sedation rates

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11
Q

extrapyramidal adverse effects

A

acute dystonia and parkinsonism onset early

tradive dyskinesia occur late

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12
Q

treatment of tardive dyskinesea

A

switch to an atypical agent
early recognition and lowest dose
reducing dose or chaning to low risk drug is best long term

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13
Q

fluphenazine

A

sedating but avalible in long lasting injections

postive symptoms

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14
Q

uses of group 1 atypical antipsychotics

A

good for postive and negative symptoms

low risk for movement disorders

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15
Q

risperidone

A

low extrapyramidal toxicity; cheapest of all atypical antipsychotics low risk for TC
FDA for MDD

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16
Q

side effects of group 1 atypical antipsychotics

A

metabolic side effects
weight pain
worsening lipid profile
dm or Cv disease development

17
Q

clozapine use

A

clozaptine first atypical drug important role in txtment of schziophrenia refractory to other txtment

18
Q

clozapine advantages

A

low risk for extrapyramidal toxicity
low rates of sedation
may effective in txtment of refractor schizophrenia

19
Q

clozapine disadvantages

A

agranulocytosis
seizures
myocarditis
orthostatic hypotension

requires CBC monitoring

20
Q

black box for all antipsychotics

A

increased momrtality in elderly dementia patients on conventional or atypical antipsychotics due to CV or infectious events

21
Q

group 2 benefits

A

low risk of weight gain and low risk of extrapyramidal side effects

22
Q

moa of ziprasidone

A

D2 antagonists and NE reuptake inhibitor and is weight neutral
take with food

23
Q

aripiprazole

A

lower rates of weight gain and lipid disorders than group 1 but slightly higher than ziprasidone

24
Q

Aripiprazole and ziprasidone are more commonly used as

A

mood stabilizers or for other various behavioral therapies than for schizophrenia

25
Q

aripiprazole FDA approval

A

for adjunct for MDD with an SSRI

26
Q

Lurasidone and ziprasidone must be taken with a

A

meal to maximize oral bioavailability

27
Q

use of lamotrigine

A

antiseizure med good for depressive phase of bipolar; acute mania and prophylaxisi of manis

28
Q

use of carbamzepine

A

bipolar acute mania prophylaxisi of acute mania

29
Q

use of valpromate

A

acute mania combo with lithim

30
Q

use of lithium

A

acute mania

used as maintenance of decrease frequency and severity of swing between depression and mania

31
Q

what reduces lithium clearance

A

renal clearance reduced by diuretics acei arbs nsaids so must monitor serum lithium levels

32
Q

s/s of lithium tox

A

Minor toxicity begins at levels between 1 to 2 mEq/L
Diarrhea, vomiting, drowsiness, muscular weakness, and a lack of coordination.
Moderate toxicity between 2 to 3 mEq/L
Giddiness, blurred vision, ataxia, tinnitus, copious dilute urine.
Major toxicity if over 3 mEq/L
High morbidity.
May require IV fluids and hemodialysis, depending on the clinical situation.

33
Q

ADE of lithium

A

tremor, increased thirst, edema

34
Q

causes of TD

A

D2 hypersensitivity

35
Q

neuroleptic malignant syndrome symptosm

A 
fever
regitidty
AMS
autonomic dysfunctiion
tachy
tachypnea 
incontinence
36
Q

Carbamazepine and lamotrigine are both used in

A

acute mania and for mania prophylaxis during euthymic or depressive phases

antipsychotics (1 decks)

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