Antipsychotics Flashcards
what is antipsychotic dopamine hypothesis?
overstimulation of DA receptors
5 examples of first generation antipsychotics
Haloperidol Fluphenazine Perphenazine Thioridazine Chlorpromazine
what is MOA of first generation
D2 receptor antagonists 5HT2c receptor antagonist alpha 1 agonist - sedates H1 antagonist - sedates, weight gain M1 antagonist - antichoinergic effects
Main side effects of alpha 1 agonists
sedation
H1 antagonist main side effects
sedation, weight gain
M1 antagonist main side effects
anticholinergic effects
5 indications of aripiprazole
schizophrenia bipolar disorder mono or adjunctive to lithium or valproate add on for major depressive disorder irritability with autisitic disorder acute treatment of agitation
asenapine indications 2
acute schizophrenia and bipolar disorder type 1 (manic, mixed)
clozapine
resistant schizo
reduce risk suicidal behavior in younger pts with schizo
iloperidone
acute schizophrenia
olanzapine
schizo and bipolar disorder manic/mixed
bipolar
resistant depression
agitation from schizo and bipolar I mania
paliperidone
schizo
schizoaffective disorder
quetiapine
schizo bipolar acute manic bipolar depression bipolar maintainance add on major depressive disorder
risperidone
schizo
bipolar mixed/ manic
irritability with autism
ziprasidone
schizo bipolar disorder (manic/mixed) bipolar maintainence
___ first drug to treat tardive dyskinesia
valbenazine
MOA valbenazine
VMAT2 inhibitor,
long term D2RA cause hyper active DA signal
valbenazine adr
somnolence, balance disorder, fall, HA< akathesia, N/V, arthralgia
black box warning for all antipsychotics
increased mortality in old pts with dementia related psychosis (CVE, pneumonia)
clozapine monitor
for agranulocytosis, get baseline WBC then weekly for 6 mo then every 2 wks for rest of tx and 4 wks after treatment is done
