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Pharm II FInal > Antipsychotics > Flashcards

Antipsychotics Flashcards

1
Q

what is antipsychotic dopamine hypothesis?

A

overstimulation of DA receptors

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2
Q

5 examples of first generation antipsychotics

A 
Haloperidol 
Fluphenazine 
Perphenazine 
Thioridazine 
Chlorpromazine
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3
Q

what is MOA of first generation

A 
D2 receptor antagonists 
5HT2c receptor antagonist 
alpha 1 agonist - sedates 
H1 antagonist - sedates, weight gain 
M1 antagonist - antichoinergic effects
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4
Q

Main side effects of alpha 1 agonists

A

sedation

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5
Q

H1 antagonist main side effects

A

sedation, weight gain

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6
Q

M1 antagonist main side effects

A

anticholinergic effects

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7
Q

5 indications of aripiprazole

A 
schizophrenia 
bipolar disorder mono or adjunctive to lithium or valproate 
add on for major depressive disorder 
irritability with autisitic disorder 
acute treatment of agitation
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8
Q

asenapine indications 2

A

acute schizophrenia and bipolar disorder type 1 (manic, mixed)

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9
Q

clozapine

A

resistant schizo

reduce risk suicidal behavior in younger pts with schizo

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10
Q

iloperidone

A

acute schizophrenia

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11
Q

olanzapine

A

schizo and bipolar disorder manic/mixed
bipolar
resistant depression
agitation from schizo and bipolar I mania

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12
Q

paliperidone

A

schizo

schizoaffective disorder

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13
Q

quetiapine

A 
schizo 
bipolar acute manic 
bipolar depression 
bipolar maintainance 
add on major depressive disorder
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14
Q

risperidone

A

schizo
bipolar mixed/ manic
irritability with autism

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15
Q

ziprasidone

A 
schizo 
bipolar disorder (manic/mixed) 
bipolar maintainence
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16
Q

___ first drug to treat tardive dyskinesia

A

valbenazine

17
Q

MOA valbenazine

A

VMAT2 inhibitor,

long term D2RA cause hyper active DA signal

18
Q

valbenazine adr

A

somnolence, balance disorder, fall, HA< akathesia, N/V, arthralgia

19
Q

black box warning for all antipsychotics

A

increased mortality in old pts with dementia related psychosis (CVE, pneumonia)

20
Q

clozapine monitor

A

for agranulocytosis, get baseline WBC then weekly for 6 mo then every 2 wks for rest of tx and 4 wks after treatment is done

Pharm II FInal (1 decks)

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