Antipsychotics

Question 1

What type of receptors do typical antipsychotics block?

Answer 1

dopamine D2 receptors

Question 2

What type of receptors do atypical antipsychotics block?

Answer 2

dopamine D2 and serotonin receptors

Question 3

What are the unfavorable side effects of atypical antipsychotics?

Answer 3

metabolic syndrome

weight gain

Question 4

Name the low potency typical antipsychotics?

Answer 4

Chlorpromazine (Thorazine)

Thioridazine (Mellaril)

Question 5

What type of side effects are common with low potency typical antipsychotics?

Answer 5

anticholinergic

antihistaminic side effects

Question 6

What happens in low potency antipsychotics overdose?

Answer 6

QTc prolongation and potential for heart block and ventricular tachycardia

Question 7

What antipsychotic causes orthostatic hypotension, bluish skin discoloration, photosensitivity?

Answer 7

chlorpromazine

Question 8

What condition is thioridazine associated with?

Answer 8

retinitis pigmentosa

Question 9

Name the midpotency typical antipsychotics

Answer 9

Lozapine (Loxitane)
thiothixene (Navane)
trifluroperazine (Stelazine)
perphenazine (Trilafon)

Question 10

Which midpotency typical antipsychotic has a higher risk of seizure?

Answer 10

Loxapine

Question 11

Which midpotency typical antipsychotic can cause ocular pigment changes?

Answer 11

Thiothixene

Question 12

Name the high potency typical antipsychotics

Answer 12

haloperidol
Fluphenazine
Pimozide

Question 13

Positive symptoms of schizophrenia are mediated through what part of the brain?

Answer 13

mesolimbic dopamine pathway

- nucleus accumbens , fornix, amygdala, hippocampus

Question 14

negative symptoms of schizophrenia are mediated through what part of the brain?

Answer 14

mesocortical pathway

Question 15

What are the side effects associated with typical antipsychotics?

Answer 15

antidopaminergic 
hyperprolactinemia
Anti histaminic, adrenergic, muscarinic 
Tardice dyskinesia 
Neuroleptic malignant syndrome

Question 16

Describe the effects of NMS?

Answer 16

Fever 
Autonomic instability ( tachycardia, labile hypertension, diaphoresis)
Leukocytosis 
Tremor 
Elevated CK 
Rigidity 
Excessive sweating 
Delirium

Question 17

name the atypical antipsychotics

Answer 17

Clozapine 
Risperidone 
Quetiapine 
Olanzapine 
Ziprasidone 
Aripiprazole 
Paliperidone 
Asenapine 
Iloperidone

Question 18

Which atypical antipsychotic is the only one to decrease risk of suicide?

Answer 18

Clozapine

Question 19

WhIch mid potency typical antipsychotic can reduce anxiety?

Answer 19

Trifluoperazine

Question 19

What are side effects of atypical antipsychotics?

Answer 19

Metabolic syndrome 
Weight gain 
Anti HAM effects 
Hyperlipidemia 
Hyperglycemia 
Liver function 
QTc prolongation

Question 20

What are the side effects of high potency typical antipsychotic?

Answer 20

EPS

Tardive dyskinesia

Question 21

Which typical antipsychotic is associated with heart block, ventricular tachycardia, and other cardiac effects?

Answer 21

Pimozide

Question 22

What are antidopaminergic effects?

Answer 22

EPS

• Parkinsonism- bradykinesia,mask like face,cogwheel rigidity, pill rolling tremor
• akathisia- subjective anxiety and restlessness, fidgeting,
• dystonia- sustained painful contractions of muscle of the neck, tongue, eyes,

Hyperprolactinemia

Question 23

How do you treat NMS caused by typical antipsychotics?

Answer 23

Dantrolene followed by bromocriptine or amantadine