Antipsychotics

Question 1

There are 4 well-defined dopamine pathways in the brain that antipsychotics act on:

Answer 1

1.
MESOLIMBIC PATHWAY
2.
NIGROSTRIATAL PATHWAY
3.
MESOCORTICAL PATHWAY
4.
TUBEROINFUNDIBULAR PATHWAY

Question 2

what neuroleptics do not have antiemetic activity?

Answer 2

Aripiprazole

Thioridazine

Question 3

Most antipsychotics are metabolized by

Answer 3

• Most antipsychotic drugs are almost completely metabolized, mainly by CYP2D6, CYP1A2 and CYP3A4.
• Antipsychotics do not interfere with the metabolism of other drugs.