Antipsychotics

Question 1

Psychosis characterized by clear sensorium but marked thinking disorder, of unknown etiology

Answer 1

Schizophrenia

Question 2

Positive symptoms of schizophrenia

Answer 2

Hallucinations
Delusions
Bizarre behavior
Neologisms, “word salad”

Question 3

Negative symptoms of schizophrenia

Answer 3

Flat affect
Poverty of speech
Avolition and apathy
Anhedonia
Social withdrawal

Question 4

Hypotheses of schizophrenia

Answer 4

Dopamine and serotonin

Question 5

All antipsychotics are _____ antagonists

Answer 5

DA (strongly block D2 receptors)

Question 6

Drugs that increase _____ can aggravate psychotic
Sx (l-DOPA, amphetamines, apomorphine)

Answer 6

DA

Question 7

Dopamine hypothesis states

Answer 7

Increased DA receptor density in brains of
schizophrenics

Question 8

Why has the dopamine hypothesis been disproved

Answer 8

Too simple (drug Tx takes weeks, anti-DA activity
within hours of dosing)

Question 9

________ and _______ act on serotonin
receptors to produce hallucinations

Answer 9

LSD and mescaline