Antipsychotics Flashcards
Antipsychotics are used to treat _____
psychosis, mania, bipolar depression, and treatment resistant unipolar depression
DSM-V Schizophrenia and Other Psychotic Disorders
Two (or more) of the following, each present for a significant portion of time during a 1-month period (or less if successfully treated):
-delusions*
-hallucinations*
-disorganized speech*
-grossly disorganized or catatonic behavior
-negative symptoms
* = at least one of the symptoms must be one of these
Symptoms must have been present at least part of the time in the last 6 months
Positive symptoms of schizophrenia
Hallucinations, delusions, formal thought disorders, bizarre/disorganized behavior.
Antipsychotics very effective in tx here
Negative symptoms of schizophrenia
Decreased eye contact, decline in grooming/hygiene, flat/blunted affect, poverty of speech, thought blocking, social withdrawal, avolition
Mesolimbic pathway (DA)
Hyperactive D2 from ventral tegmental area to nucleus accumbens is associated with positive symptoms of schizophrenia
Mesocortical pathway (DA)