Antipsychotics Flashcards

1
Q

Antipsychotics are used to treat _____

A

psychosis, mania, bipolar depression, and treatment resistant unipolar depression

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2
Q

DSM-V Schizophrenia and Other Psychotic Disorders

A

Two (or more) of the following, each present for a significant portion of time during a 1-month period (or less if successfully treated):
-delusions*
-hallucinations*
-disorganized speech*
-grossly disorganized or catatonic behavior
-negative symptoms
* = at least one of the symptoms must be one of these
Symptoms must have been present at least part of the time in the last 6 months

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3
Q

Positive symptoms of schizophrenia

A

Hallucinations, delusions, formal thought disorders, bizarre/disorganized behavior.
Antipsychotics very effective in tx here

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4
Q

Negative symptoms of schizophrenia

A

Decreased eye contact, decline in grooming/hygiene, flat/blunted affect, poverty of speech, thought blocking, social withdrawal, avolition

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5
Q

Mesolimbic pathway (DA)

A

Hyperactive D2 from ventral tegmental area to nucleus accumbens is associated with positive symptoms of schizophrenia

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6
Q

Mesocortical pathway (DA)

A
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