antipsychotics

Question 1

Typical antipsychotics (1st generation)

Answer 1

Chlorpromazine
Acetaphenazine
Fluphenazine
Trifluoperazine
Triflupromazine
Haloperidol

Question 2

Typical Antipsychotics MOA

Answer 2

Blockade of Dopamine (D2) receptors causing:
Reduced positive symptoms
Less effective treating negative symptoms

(by blocking the effect of dopamine on the brain)

Question 3

Typical Antipsychotics Side effects

Answer 3

Too much D2 blockade leads to EPS motor abnormalities (parkinsonism), tardive dyskinesia or hyperkinetic movement disorder

Neuroleptic Malignant Syndrome

Sedation

Anticholinergic effects

Hyperprolactinemia

Question 4

Atypical antipsychotics (2nd generation)

Answer 4

Aripiprazole (Abilify)
Clozapine (Clozaril)
Olanzapine   (Zyprexa)
Quetiapine   (Seroquel)
Risperidone (RIsperdal)
Ziprasidone  (Geodon)
Paliperidone (Invega)
Lurasidone (Latuda)

Question 5

Atypical antipsychotics MOA

Answer 5

Effect on multiple dopamine pathways as well as serotonin pathways reducing negative and positive symptoms

Question 6

Atypical antipsychotics SE

Answer 6

Decreased incidence of EPS
SIGNIFICANT incidence of metabolic syndrome, weight gain, diabetes
Monitor labs regularly

Question 7

Safety of Antipsychotics

Answer 7

Increased Mortality in Elderly Patients With Dementia-Related Psychosis

Suicidal behavior when combined with antidepressants