Antipsychotic Drugs

Question 1

Most widely used first generation antipsychotic drug

Answer 1

Haloperidol

Question 2

Dopamine receptor that is coded on Chromosome 11, Gi coupled and found pre and post synaptically on neurons in the caudate-putamen, nucleus accumbens and olfactory tubercle

Answer 2

D2 receptor

Question 3

Dopamine receptor found in the frontal cortex, medulla and midbrain

Answer 3

D3 receptor

Question 4

Average time for relapse in stable patients with schizophrenia who discontinue their drugs

Answer 4

6 months

Question 5

This drug has rapid and severe relapse after discontinuation

Answer 5

Clozapine

Question 6

Dopamine receptor in chrom 5, Gs coupled mainly in the putamen, nucleus accumbens, olfactory tubercle and cortex

Answer 6

D1 receptor

Question 7

Dopamine receptor in chrom 4, found in the hippocampus and hypothalamus

Answer 7

D5 receptor

Question 8

EPS is due associated with this dopamine receptor

Answer 8

D2 receptor

Question 9

Second generation antipsychotic with 5HT 2A antagonism and very high occupancy of D2 receptors, does not cause EPS because of its partial D2 receptor agonist.

Answer 9

Aripiprazole

Question 10

Antipsychotic approved for PD

Answer 10

Pimavanserin

Question 11

Small percentage of patients develop diabetes with these antipsychotics and also increase in weight and lipids

Answer 11

Clozapine, Olanzapine

Question 12

The only second generation antipsychotic drug approved to reduce the risk of suicide in patients with history of Schizophrenia

Answer 12

Clozapine

Question 13

Side effect of Clozapine

Answer 13

Agranulocytosis and seizures

Question 14

May be given to patients who are refractory to other antipsychotics

Answer 14

Clopazine or high dose Olanzapine

Question 15

Most important unwanted effect of antipsychotic drug

Answer 15

Tardive dyskinesia

Question 16

Drug class of Clozapine

Answer 16

Dibenzodiazepine

Question 17

Endocrine effect of antipsychotics

Answer 17

Increase prolactin level especially older typical antipsychotics, Risperidone and paliperidone

Question 18

The only antipsychotic drug that causes retinal deposits which in advance cases may resemble retinitis pigmentosa causing “browning” of vision.

Answer 18

Thioridazine

Question 19

Atypical antipsychotic with greatest risk of QT prolongation

Answer 19

Ziprasidone

Question 20

May cause myocarditis

Answer 20

Clozapine

Question 21

This syndrome is believed to result from an excessively rapid blockade of postsynaptic dopamine receptors

Answer 21

Neuroleptic Malignant syndrome

Question 22

First agent shown to be useful in the treatment of manic phase of bipolar disorder that was not also an antipsychotic

Answer 22

Lithium

Question 23

This drug suppresses inositol signaling through depletion of intracellular inositol and inhibits glycogen synthetase kinase 3 GSK 3

Answer 23

Lithium

Question 24

Definite contraindication to the use of Lithuim

Answer 24

Bradycardia-tachycardia sick sinus syndrome

Question 25

This antiepileptic reduces the frequency of recurrent depressive cycles and may have some utility in the treatment of bipolar depression

Answer 25

Lamotrigine

Question 26

Most common adverse effect of lithium

Answer 26

tremor