antipsych Flashcards
What are the First Gen antipsychotics
chlorpromazine thioridazine perphenazine, fluphenazine haloperidol ,
FGAs SE
all are sedating and cause EPS, tardive dyskineasias, dystonias, akathisia, dyskinesias, sexual dysfunction, cardiovascular effects, orthostasis, QT prolongation
Clozaril, FazaClo ODT
clozapine, SGAs, SE: agranulocytosis, seizures
Zyprexa, Zydis ODT
olanzapine, SGAs, PO at QHS bc long acting & sedating, IM & ODT,SE: sedation, weight gain, increase lipids & glucose
Risperdal, Risperdal M-Tabs ODT, Risperdal Consta injection
risperidone, SGAs, SE: EPS, increase prolactin (sexual dysfunction, galactorrhea, irregular/missed periods), weight gain, increase lipids & glucose
Seroquel, Seroquel XRT
quetiapine, SGAs, SE: sedation, orthostasis, weight gain, increase lipids & glucose
Geodon
ziprasidone, SGAs, IM injection, SE: prolongs QT interval CI in QT risk
Abilify, Abilify Discmelt ODT
aripiprazole, SGAs, IM injection, SE: anxiety, insomnia
Invega, Invega Sustenna LA monthly injection
paliperidone, SGAs, SE: increase prolactin, ESP esp higher doses, 3 mg if CrCl < 50, active metabolite of risperidone
Fanapt
iloperidone, SGAs
Saphris
asenapine, SGAs,subllingual tablet, SE: tongue/mouth numbness
Latuda
lurasidone, SGAs
SGAs risl for metabolic effect (weight gain, elevated lipids, BP & blood glucose) in order with highest as 1
olanzapine, quetiapine, clozapine, risperidone, paliperidone
What is the pneumonic for anticholinergic side effects
Blind as a Bat ( visual changes) Mad as a hatter( confusion) Red as abeet ( flushing) Hot as a hare (hyperthermia) Dry as a bone (constipation, dry mouth) but can’t pee ( urinary retention)
what is the definistion of Dsytonia
painful, involuntary muscle spasms in skeletal muscles
Dystonic reactions occur in which muscles?
the muscles of the face, & neck are the most common. Back, arms, & leg muscles
When do dystonic reactions typiclaly occur?
24-96 hours after starting or changing dose
What effect do antipsychotics have on dopatime which leads to what?
antipsychotics cause a decrease in domapine which leads to pseudoparkinsonism
How is Dystonia trea?ted
Cogentin (benztropine) 1-2mg IM or Benadryl (diphenhydramine) 25-50mg IM q30min until reaction is goine
What is the subjective feeling of discomfromt, manifested as motor restlessness of legs (inablity to stand or sit still)
Akathisia
When does akathisia usually present
weeks of therapy initiation
Lipophilic BB (propranolol) BZDs, clonidine & anticholinergics are used to treat what antipsychotic therpay SE
Akatheisia
There is black box warning for QT prolongation for this Typical Antipsychotic
Thoridazine
At what dose is a patient on Mellaril at risk of pigemntary retinopathy (cataract)?
> 800mg/d
