Antiprotozoals Flashcards
1
Q
What do antiprotozoal drugs act upon?
A
- Cellular integrity
2. Biosynthesis of essential factors and macromolecules
2
Q
What do trivalent organic arsenicals react with?
A
Thiol groups in co-factors and enzymes
3
Q
What do trivalent organic arsenicals ultimately inhibit?
A
ATP synthesis
4
Q
How do Plasmodium trophozoites obtain amino acids for biosynthesis?
A
Digest haemoglobin in erythrocytes
5
Q
Where does biosynthesis take place in the Plasmodium?
A
Food vacuole of the parasite
6
Q
How does Plasmodium prevent toxic build up of free haem?
A
Polymerises haem into non-toxic crystals of haemozoin
7
Q
What is the metabolic pathway for folate production dependent on?
A
P-aminobenzoate
