Antiprotozoal Drugs

Question 1

Be able to ID the DOC for amebiasis, giardiasis, trichomoniasis, toxoplasmosis, leishmaniasis, and trypanosomiasis using a chart. Also identify any important notes you need to remember about treatment.

Answer 1

Question 2

Prophylactic treatment for malaria in chloroquine-sensitive regions?

Answer 2

chloroquine +/- primaquine

Question 3

What is the most common cause of malaria and then name the 2nd common cause? (The bug name)

Answer 3

P. vivax
P. falciparum

(P) = plasmodium

Question 4

Best treatment for P. vivax?

Answer 4

chloroquine + primaquine

Question 5

Best treatment for P. falciparum even though it doesn’t respond great to this treatment well?

Answer 5

chloroquine

Question 6

S/E of the “quin” drugs?

Answer 6

hemolytic anemia in G6PD deficiency (primaquine, quinine)

cinchonism

Question 7

What are the best drugs for treatment of nematodes?

Answer 7

bendazoles

albendazole
mebendazole

and pyrantel pamoate

Question 8

What are common nematode names?

Answer 8

hookworms, roundworms, pinworms

Question 9

What is the MOA of albendazole?

Answer 9

dec glucose uptake and dec microtubular structure

Question 10

MOA of pyrantel pamoate?

Answer 10

Nm agonist > spastic paralysis

like giving the helminth succinylcholine

Question 11

What is another name for cestodes and trematodes?

Answer 11

tapeworms, flukes respectively

Question 12

What is the DOC for treatment of cestodes and trematodes?

Answer 12

praziquantel

Question 13

Praziquantel MOA

Answer 13

inc. Ca2+ influx, inc vacuolization