Antiplatlets

Question 1

P2y12 receptor inhibitors …main site for ADP binding on platlet cell

Answer 1

Clopidogrel
Ticlopidine
Ticagrelor
Prasugrel

Question 2

Gp2a3b inhibitors

Answer 2

Tirofiban
Eptifibatide

Question 3

Phosphodiesterase 3 INnhibitors

Answer 3

Dipyridamole
Cylostazol

Question 4

Medication that work via platelet plug formation (antiplatlets)

Answer 4

P2y12 receptor inhibitors (clopidogrel,prasugrel,ticagrelor)
Gp3a2b receptor inhibitors (tirofiban,Eptifibatide)
Pde-3 inhibitors (dipyridamole)
Cox inhibitors (aspirin, nsaids)

Question 5

Heparin mechanism of action

Answer 5

stimulates antithrombin III -which prevents the activation of II, VII, IX, X, XI, XII

Question 6

Heparin agents and moa

Answer 6

STIMULATES ANTITHROMBIN III
Heparin.- stimulates antithrobin III -(inhibits x and Ii)
LMWH - inhibits X>II
ULtra LMWH - fondaparinux - inhibits X

Question 7

Factor 10a inhibitors

Answer 7

Apixaban (Eliquis)
Rivaroxaban (Xarelto)
Edoxaban

Question 8

Direct Thrombin Inhibitors

Answer 8

Dabigatran (oral)
Bivalirudun
Argatroban

Question 9

Doac (direct oral anticoagulants)

Answer 9

Direct thrombin inhibitors -dabigatran
Factor 10a inhibitors - apixaban, rivaroxaban, edoxaban

Question 10

Vitamin k antagonist -(vit k epoxide reductive inhibitor) prevent vit k from being in reduced form which doesn’t activate GGT then activation II, VII,Ix, X)

Answer 10

Warfarin

Question 11

Clopidogrel

Answer 11

P2y12 receptor inhibitors (plavix)

Question 12

Prasugrel

Answer 12

P2y12 receptor inhibitors (Efient)

Question 13

Ticagular

Answer 13

P2y12 receptor inhibitors (Brilinta)

Question 14

RIVAROXABAN

Answer 14

XARELTO - factor10a inhibitors

Question 15

Apixaban

Answer 15

Eliquis Factor 10a inhibitors

Question 16

Argatroban

Answer 16

Novastan. Direct thrombin inhibitor -Used for heparin induced thrombocytopenia

Question 17

Bivalirubin

Answer 17

Direct thrombin inhibitor (potential benefit in pediatric ecmo cases - reduction in transfusion requirements)

Question 18

Dabigatran

Answer 18

Pradexa - oral direct thrombin inhibitor

Question 19

Dabigatran

Answer 19

Pradexa

Question 20

Dabigatran antidote

Answer 20

Idarucizumab

Question 21

Fibrinolytics mechanism of action

Answer 21

converts of plasminagen to plasmin via tissue plasminagen activator - breaks clot

Question 22

Drugs which increase TPA -

Answer 22

Altaplase
Retroplase
Tenectaplase
Urokinase
Streptokinase