AntiPlatelets (week 2)

Question 1

What is the regular dosage of Dabigatran (Pradaxa)?

Answer 1

220 mg daily

Question 2

What are indications of dabigatran?

Answer 2

Treatment of DVT & PE

Stroke and embolus prevention

Question 3

What is the MOA of dabigatran?

Answer 3

Direct inhibitor of thrombin

Question 4

What are the advantages of dabigatran( Pradaxa)?

Answer 4

Rapid onset
No anticoagulation monitoring
Few drug-food interactions
Lower risk of major bleeding

Question 5

What are the disadvantages of dabigatran (Pradaxa)?

Answer 5

Dosing on time is important

THERE IS NO ANTIDOTE

Question 6

What is the regular dosing for aspirin?

Answer 6

81 mg for chronic use/old people

325 mg for initial treatment

Question 7

What are indications for aspirin?

Answer 7

Ischemic stroke
TIA's
Chronic stable angina
Unstable angina 
Coronary stenting
Acute MI

Question 8

What is the MOA of Aspirin?

Answer 8

Suppresses platelet aggregation by causing irreversible inhibition of COX.

Question 9

What are the adverse effects of Aspirin?

Answer 9

Risk for GI bleeding

Hemorrhagic stroke

Question 10

What should the nurse include in the plan of care for patients on aspirin?

Answer 10

Bleeding precautions
Do not administer other NSAIDS
Monitor for tarry stools

Question 11

What is the regular dose of Clopidogrel (Plavix)?

Answer 11

75 mg

Question 12

What are indications for Clopidogrel (Plavix)?

Answer 12

Preventing blockage of coronary artery stents

Reduction of thrombotic events in patients with ACS

Question 13

What is the MOA of Clopidogrel (Plavix)?

Answer 13

Blocks ADP receptors on platelets and thereby prevents ADP-stimulated platelet aggregation

Question 14

What kind of drugs interact with Clopidogrel (Plavix)?

Answer 14

Drugs that promote bleeding

PPI’s

Question 15

What are nursing considerations for Clopidogrel (Plavix)?

Answer 15

Determine date of last use is patient is scheduled for a surgical procedure. Withdraw 5 days before surgery.