Antiplatelets Flashcards
1
Q
What are the actions of the anti-platelets?
A
- Inhibit platelet activation
* Inhibit platelet aggregation
2
Q
How are the actions of platelets achieved?
A
- Platelet receptor inhibition
* Platelet signalling inhibition
3
Q
What is the mechanism of action of clopidogrel and ticlodipine?
A
- Irreversible blockage of the ADP receptor
- Decreases the expression of glycoprotein IIb and IIIa
- Reduced binding to fibrinogen
4
Q
What is the mechanism of action of abciximab and tirofiban?
A
- Monoclonal antibodies antagonise IIb and IIa receptor so fibrinogen can’t bind
- Reduced platelet aggregation
- Reduced binding of fibrinogen
5
Q
What is the mechanism of action of aspirin?
A
- Irreversible inhibition of cyclooxygenase
- Blocks conversion of arachidonic acid to thromboxane A2
- Decreases platelet activation
6
Q
What is dipyridamole?
A
Phosphodiesterase III inhibitor
7
Q
What is the mechanism of action of dipyridamole?
A
- Increased platelet concentration of cAMP
- Increased cAMP leads to decreased platelet responsiveness to ADP
- Reduced platelet aggregation
8
Q
What is picotamide?
A
Thromboxane synthesise inhibitor and thromboxane receptor blockers
9
Q
What are the indications of anti platelets?
A
- Cardiovascular disease
- Acute MI (aspirin indefinitely, clopidogrel up to 12 months)
- Secondary prevention of CVD (aspirin)
- Cerebrovascular disease (without AF)
- Acute stroke/TIA/sceondary prevention (clopidogrel or aspirin and dipyridamole)
- Peripheral vascular: Clopidogrel or aspirin if it isn’t tolerated
