Antiplatelet/Anticoagulant/Fibrinolytic Meds

Question 1

what is the MOA for aspirin?

Answer 1

irreversibly inactivates cyclooxygenase (COX-1)

Question 2

What is the MOA for clopidogrel, prasugrel, and ticopidine (thienopyridines)?

Answer 2

irreversibly bloc P2Y12 component of the ADP receptor

Question 3

What is the MOA for ticagrelor and cangrelor?

Answer 3

reversibly bloc P2Y12 component of the ADP receptor

Question 4

What is an example of a phosphodiesterase inhibitor?

Answer 4

cilostazol

Question 5

adenosine reuptake inhibitor

Answer 5

dipyridamole

Question 6

glycoprotein IIb/IIIa inhibitors

Answer 6

tirofiban, eptifibatide (both IV only)

Question 7

inhibits thrombin-mediated platelet activation targeting PAR-1 receptor

Answer 7

vorapaxar

Question 8

bind adhesion molecules, fibrinogen and VWF

Answer 8

abciximab, eptifibatide, tirofiban

Question 9

antiplatelets

Answer 9

aspirin, clopidogrel, prasugrel, ticlopidine, ticagrelor, cangrelor, cilostazol, dipyridamole, tirofiban, eptifibatide, vorapaxar

Question 10

irreversible cyclooxygenase inhibitor

Answer 10

aspirin

Question 11

PAR-1 antagonist

Answer 11

vorapaxar