antiparasitics

Question 1

tx for scabies, organism?

Answer 1

sarcoptes scabei var hominis
BBC SLIP = BBC S (10%)
benzoyl benzoate 10%
crotamilton 10%
sULFUR 5-10%
lindane 1%
ivermectin 200 mg/kg
permethrin 5%

Question 2

tx for head lice?

Answer 2

MD SIP

malathion 0.5%
Dimethicone

SPinosad 0.9% cream rinse
ivermectin >15 kg 200 mcg/kg
permethrin cream rinse 1% 
pyrethrin 0.33% 
permethrin 5%

Question 3

PERMETHRIN 5% FOR scabies instructions? MOA?

Answer 3

Overnight day 1 and 8
rince
FDA > 2 mo, prego B
avoid in formaldehyde allergy

MOA: permethriNNNN - > Na+ channel blockade -> paralysis

Question 4

permethrin instructions for head lice 1%? 5% 0.33% MOA?

Answer 4

Pyrethrin 0.33% 10 minutes to dry hair, c/i if allergy to chrysanthemum
head lice only

1% - 10 minutes (1x 10) on DRY HAIR = Nix
only for head lice

5% - OVERNIGHT to clean dry hair = KWELADA
headline and scabies

Question 5

Malathion MOA? Dimethicone MOA? lindane ?

Answer 5

malathion 0.5% overnight - organophosphate, Ch esterase inhibitor, not in canada, flammable
`
dimethicone overnight – silicone, closes respiratory spiracles

lindane - neuroleptic -> blocks gaba - < 10 mins 1%

Question 6

spinosad MOA?? directions?

Answer 6

10 mins to dry hair 0.9%

MD - OVERNIGHT
SIPP - 10 minutes except last P 5% - overnight

Question 7

ivermectin MOA in lice/scabies? instructions? age?

Answer 7

> 15 kg, category C, do not breastfeed
PO 200 mag/kg, day 0 and 8

glutamate gated chloride channel blockade

Question 8

difference between pyrethrin and permethrin? how do you apply for scabies?

Answer 8

pyrethrin natural 0.33%
permethrin is synthetic

> 2 mo

neck down for scabies
face/neck and toes in infants/young/elderly
per WOLVERTON wash clothes/linens used in 24 hrs - cannot survive for long
TREAT ALL CLOSE CONDACTS

head lice:
shampoo hair - NO CONDITIONER -> TOWEL dry -> apply on scalp and back of ears x 10 mins, rinse

Question 9

agents available for Crabs?

Answer 9

permethrin 1% - rinse after 10 minutes
permethrin 5% overnight

1% 10 - 5% ON
lindane 1% CNS toxiity
ivermectin
vaseline on lashes

Question 10

SULFUR - how to apply for scabies? age?

Answer 10

OVERNIGHT (ideally 24 hrs) x 3 days, safe in infants