Antineoplastics Flashcards
1
Q
Why use methotrexate and leucovorin together?
A
High doses of methotrexate to bind all DHFR to attack cancer cells, rescue with leucovorin to bypass this in normal cells
2
Q
What is the importance of TPMT?
A
t tolerate 6-mercaptopurine
10% of pts have 1 nonfunctional copy and need a reduced dose to prevent bone marrow toxicity
