Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Antineoplastic Pharmacology > Antineoplastic Pharmacology > Flashcards

Antineoplastic Pharmacology Flashcards

1
Q

Prednisone, Desamethasone (Glucocorticoid)

A

CCS - G1
Mechanism: Induce apoptosis
Adverse effects: body fluid retention, hyperglycemia, weight gain, euphoria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Diethylsilbestrol, Testosterone (Gonadal hormones)

A

CCS - G1
Mechanism: Cytostatic
Adverse effects: Androgen - cholestatic jaundice
Estrogen - N/V, hypercalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Tamoxifen (Gonadal Hormone Antagonist)

A

CCS - G1
Mechanism: Estrogen receptor blocker
Adverse effects: hot flashes, fluid retention

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Flutamide (Gonadal Hormone Antagonist)

A

CCS - G1
Mechanism: androgen receptor blocker
Adverse effects: gynecomastia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Leuprolide/Goserelin (Gonadotropin-releasing Analog)

A

CCS - G1
Mechanism: decrease FSH/LH
Adverse effects: transient flare of symptoms in patients with bone metastasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Anastrozole (Aromatase inhibitors)

A

CCS - G1
Mechanism: Inhibits formation of estrogen
Adverse effects: Nausea, asthenia, headache, hot flashes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

L-Asparaginase

A

CCS - G1
Mechanism: deplete serum asparagine needed for growth
Adverse effects: Hypersensitivity, inhibit protein synthesis leads to decrease clotting factors, hypoalbuminemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Methotrexate (antimetabolite)

A

CCS - S
Mechanism: analog of folic acid; inhibits DHFR –> depletes bases needed for DNA synthesis
Adverse effects: Myelosuppression, GI toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Methotrexate Co-perscription

A

Folinic Acid help with toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Methotrexate Overdose

A

Glucarpidase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

6-Mercaptopurine (antimetabolite)

A

CCS - S
Mechanism: inhibit puren metabolism after activation by HGPRT; incorporated into DNA/RNA
Adverse effects: Bone marrow suppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Cytarabine (antimetabolite)

A

CCS - S
Mechanism: activated by tumor cell kinases to inhibit pyrimidine metabolism
Adverse: bone marrow suppression, N/V

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

5-Fluorouracil (antimetabolite)

A

CCS - S
Mechanism: Inhibits thymidylate synthase –> thymine-less death
Adverse: diarrhea, bone marrow suppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Bleomycin (antibiotics)

A

CCS - G2
Mechanism: Alters nucleis acid fxn via free radicals
Adverse: Pulmonary fibrosis, skin thickening
BONE MARROW SPARING

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Etoposide

A

CCS - late S/early G2
Mechanism: Toposiomerase II inhibitor
Adverse: Neutropenia, N/V, diarrhea, hepatic dysfxn (high levels)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Vincristine, Vinblastine

A

CCS - M phase
Mechanism: Binds tubulin & blocks mitotic spindle assembly
Adverse: VC - neurotoxic; VB - bone marrow suppression

17
Q

Paclitaxel

A

CCS - M phase
Mechanism: Block mitotic spindle disassembly (opposite of VC/VB)
Adverse: peripheral neuropathy, myelosuppression

18
Q

Cisplatin

A

CCNS
Mechanism: Covalently bind DNA –> abnormal base pairing/strand breakage
Adverse: Peripheral neuropathy, renal insufficiency
BONE MARROW SPARING

19
Q

Cyclophosphamide

A

CCNS
Mechanism: covalently bind DNA
**Activated by CytP450
Adverse: forms acrolein, causing bladder toxicity

20
Q

Carmustine

A

CCNS
Mechanism: highly lipid soluble –> alkylating
Adverse:leukopenia, pulmonary fibrosis, N/V

21
Q

Procarbazine

A

CCNS
Mechanism: Effects on DNA
**NEEDS activated by CytP450
Adverse: leukemia, bone marrow suppression, N/V

22
Q

Doxorubicin

A

CCNS
Mechanism: Inhibit topoisomerase II + free radicals
Adverse: Myelosuppression, cardiotoxicity is dose-limiting

23
Q

Dactinomycin

A

CCNS
Mechanism: inhibits DNA-dep RNA synthesis
Adverse: Bone marrow suppression

24
Q

Daunorubicin

A

CCNS
Mechanism: Inhibit topoisomerase II + free radicals
Adverse: Myelosuppression, cardiotoxicity is dose-limiting

25
Q

Mitomycin

A

CCNS
Mechanism: biotransform to alkylating agent
Adverse: Bone marrow suppression

26
Q

Interferon-alpha

A

Mechanism: Inhibition of viral replication, suppress cell proliferation, augment lymphocyte cytotoxicity
Adverse: Myelosuppression, neurotoxicity
**Not commonly used unless maybe T cell lymphoma

27
Q

Rituximab (monoclonal antibodies)

A

CCNS
Mechanism: Interacts with surface protein (CD20) on normal/malignant B lympocytes
Adverse: myelosuppression, hypersensitivity

28
Q

Imatinib

A

CCNS
Mechanism: Inhibits abnormal tyrosine kinase made by Philadelphia chromosome
Adverse: diarrhea, nausea, cramps, fatigue

Antineoplastic Pharmacology (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions