Antineoplastic Drugs

Question 1

Drug of choice for pancreatic cancer

Answer 1

Gemcitabine
Erlotinib(tyrosine kinase inhibitor ) is also used

Question 2

Drug of choice for multiple myeloma

Answer 2

Melphalan

Question 3

Hemorrhagic cystitis is caused by

Answer 3

Cyclophosphamide

Question 4

Treatment for hemorrhagic cystitis

Answer 4

Hydration and use of mercaptoethanesulfonate (mesna)

Question 5

Drugs used in treatment Gliomas (brain tumors)

Answer 5

Nitrosoureas - carmustine , lomustine , semustine – used because they are highly lipid soluble and can cross blood brain barrier . But they can cause neutropenia

Question 6

Drug used in chronic lymphocytic leukemia (CLL)

Answer 6

Fludarabine

Question 7

Drug used in Hodgkins lymphoma

Answer 7

Mechloethamine
It has ability to cause lymphocytopenia

Question 8

Disulfiram like reaction with alcohol is caused by

Answer 8

Procarbazine

Question 9

Inhibitor of dihydrofolate reductase and thymidylate synthase is

Answer 9

Methotrexate

Question 10

What is leucovorin rescue

Answer 10

The toxic effects of methotrexate on normal cells may be reduced by administration of folinic acid (leucovorin)

Question 11

Methotrexate cleaving enzyme

Answer 11

Glucarpidase - in extreme cases , toxicity of methotrexate can be treated by dialysis or administration of glucarpidase

Question 12

Drug for mesothelioma

Answer 12

Pemetrexed

Question 13

HGPRTase ?

Answer 13

Hypoxanthine -gaunine phosphoribosyl transferases

Question 14

Drug of choice for hairy cell leukemia

Answer 14

Cladribine

Question 15

Oral prodrug of 5-Fluorouracil

Answer 15

Capecitabine

Question 16

Oral treatment of 5-Fluorouracil and capecitabine toxicity

Answer 16

Uridine triacetate

Question 17

Treatment for myelodysplasia

Answer 17

5’-Azacytidine