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Phar 140 > Antimycobacterials > Flashcards

Antimycobacterials Flashcards

1
Q

Moa of cycloserine: inhibits

A

d- alanine racemase

D- alanyl- D- alanine synthetase

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2
Q

Adverse effects of cycloserine

A

CNS dysfunction

peripheral neuropathy

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3
Q

Para-aminosalicylic acid moa: inhibits

A

Folate synthesis

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4
Q

para-aminosalicylic acid generates __________ which inhibits dihydrogolate reductase

A

Hydroxyl dihydrofolate antimetabolite

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5
Q

Adverse effects of PAS

A

GI symptoms
Peptic ulceration and bleeding
Hypersensitivit

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6
Q

Treatment of TB caused b streptomycin resistant strains

A

Amikacin and Kanamycin

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7
Q

Tx for typical Mycobacteria

A

Ofloxacin- 600-800 mg PO

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8
Q

Tx for atypical Mycobacteria

A

Ciprofloxacin- 750 mg PO 2x a day

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9
Q

CIprofloxacin and Ofloxacin inhibits

A

Topoisomerase II

Topoisomerase IV

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10
Q

Relaxes the supercoiled DNA strands as preparation for normal replication

A

Topoisomerase II

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11
Q

Participates in the separation of replicated DNA chromosomes into 2 daughter cells during cell division

A

Topoisomerase IV

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12
Q

Used as last resort for multi drug resistant TB

A

Clofazimine

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13
Q

M. Leprae&raquo_space;> M. Tuberculosis

A

clofazimine

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14
Q

Only anti-TB that has teratogenic effect

A

Streptomycin

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15
Q

Teratogenic effect of streptomycin

A

congenital deafness

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16
Q

T/F Breast feeding should not be discourage for women being treated with 1st line drugs.

A

T

17
Q

Origin of cycloserine

A

Streptomyces orchidaceus

Phar 140 (1 decks)

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