Antimuscarinics Flashcards
What are common side effects of all antimuscarinics
dry mouth, tachycardia, blurred vision, drowsiness, consipation, confusion
What drugs do they all interact with?
TCA
ANTIMUSCARINICS-GENITOURINARY
What are examples of their use in genitourinary
Solifenacin
Oxybutnin
Tolteridone
ANTIMUSCARINICS-GENITOURINARY
What are three different types of overactive bladder and how are they characterised?
Urinary frequency- abnormal frequent urination
Urinary urgency- sudden strong need to urinate
Urinary incontinence-loss of bladder control
ANTIMUSCARINICS-GENITOURINARY
What is first line?
What is second line?
1: pelvic floor exercises, bladder training, weight loss, caffeine reduction
2: antimuscarinics
ANTIMUSCARINICS-GENITOURINARY
What is their mechanism of action?
Block muscarinic receptors (M3) , promoting smooth muscle relaxation
ANTIMUSCARINICS-GENITOURINARY
What drug is most likely to cause side effects and why?
Oxybutynin as it is lipid soluble so readily crosses the BBB, acts on M1 receptor
Solifenacin most specific to M3 receptors so less side effects
ANTIMUSCARINICS-GENITOURINARY
What group of people should NOT be prescribed this?
patients with UTI
urinary retention
Caution;
Elderly due to cognitive impairment
Angle closure glaucoma
Arrythmias
ANTIMUSCARINICS-GENITOURINARY
What are dosages?
2mg tolteridone
Solifenacin 5mg OD
ANTIMUSCARINICS-CARDIO/GI
What are indications?
Cardio;
atropine and glycopyrronium are first line in management of severe or sympathetic bradycardia to increase heart rate
GI; Atropine and hyoscine butyl bromide are used for IBS
Palliative care to prevent to reduce noisy respiratory secretions
ANTIMUSCARINICS-CARDIO/GI
which drugs have fewer central nervous system effects?
Quaternary ammonium compounds;
Glycopyronium and hyoscine butlybromide
