Antimicrobials Lecture

Question 1

General name of antimicrobials that KILL bacteria

Answer 1

Bactericidal antimicrobials

Question 2

General name of antimicrobials that INHIBIT GROWTH of bacteria?

Answer 2

Bacteriostatic

Question 3

Does Penicillin G work on Gram-negative bacteria?

Answer 3

No, they don’t have enough peptidoglycan in their cell wall

Question 4

What are the five ways antimicrobials act?

Answer 4

Inhibition of cell wall synthesis
Inhibition of protein synthesis
Injury to the plasma membrane
Inhibition of nucleic acid synthesis
Inhibition of essential metabolite synthesis

Question 5

Which antibiotics act by inhibiting cell wall synthesis?

Answer 5

Beta-lactam antibiotics e.g. Penicillin G, cephalosporins, carbapenems

Question 6

Name some drugs that interfere with protein synthesis

Answer 6

Aminoglycosides (e.g. Streptomycin and gentamicin)
Tetracyclines
Chloramphenicol
Macrolides

Question 7

Drugs that inhibit nucleic acid synthesis examples

Answer 7

Quinolones

Rifamycins

Question 8

Drugs that disrupt cell wall / membrane integrity

Answer 8

Polymyxins

Question 9

Drugs that inhibit essential metabolite synthesis

Answer 9

Sulfonamides