Antimicrobials And Antivirals Flashcards

1
Q

Amantadine

A

Antiviral
Inhibits penetration and uncoating
Can only be used topically

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2
Q

Aciclovir

A

Antiviral
Prodrug phosphorylated three times
DNA polymerase inhibitor
Should be selective for virus infected cells

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3
Q

Idoxuridine/trifluridine

A

Antiviral
Incorporated into DNA but stands cant join.
Only used topically as infects all cells

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4
Q

Azidothymidine/zidovudine

A

Antiviral
Prodrug
Reverse transcriptase inhibitor

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5
Q

Beta lactams

A

Antibiotic

Target transleptidases preventing cross linking of cells walls

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6
Q

Tetracyclines

A

Antibiotic

Competition with tRNA for A site during translation

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7
Q

Aminoglycosides

A

Antibiotic

Miss reading of message

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8
Q

Chloramphenicol/ florfenicol

A

Antibiotic

Inhibits peptide bond formation during protein synthesis

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9
Q

Macrolides

A

Antibiotic

Inhibits translocation

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10
Q

Sulphonamides and trimethoprim

A

Antibiotic
Inhibit folate synthesis
PABA—> folate —> tetrahydrofolate

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