Antimicrobials And Antivirals Flashcards
Amantadine
Antiviral
Inhibits penetration and uncoating
Can only be used topically
Aciclovir
Antiviral
Prodrug phosphorylated three times
DNA polymerase inhibitor
Should be selective for virus infected cells
Idoxuridine/trifluridine
Antiviral
Incorporated into DNA but stands cant join.
Only used topically as infects all cells
Azidothymidine/zidovudine
Antiviral
Prodrug
Reverse transcriptase inhibitor
Beta lactams
Antibiotic
Target transleptidases preventing cross linking of cells walls
Tetracyclines
Antibiotic
Competition with tRNA for A site during translation
Aminoglycosides
Antibiotic
Miss reading of message
Chloramphenicol/ florfenicol
Antibiotic
Inhibits peptide bond formation during protein synthesis
Macrolides
Antibiotic
Inhibits translocation
Sulphonamides and trimethoprim
Antibiotic
Inhibit folate synthesis
PABA—> folate —> tetrahydrofolate