Antimicrobials Flashcards
1
Q
Nucleoside reverse transcriptase inhibitors
A
Tenofovir, entecavir
MOA
- analogues of nucleosides
- inhibits viral replication
- HIV
- > inhibits viral RNA dependent DNA polymerase
- HBV
- > inhibits HBV polymerase
SE
- diarrhoea
- nausea
- vomiting
- dizziness
2
Q
Acyclovir
A
SE
- AKI
- > crystallization in the renal tubules
- > occurs with dehydration
- neutropenia
- > dose-dependent
- > reversible
- Ulceration
- > at the site of peripheral extravasation
- Seizures
