Antimicrobials Flashcards
Macrolides
Macrolides Gram positive bacteria Protein synthesis is inhibited by drug binding to receptors on the 50S ribosomal subunit and subsequent disruption of the growing peptide chain Bacteriostatic Ex: Erythromycin
Aminoglycosides
“Aminoglycoside
Gram positive and negative bacteria (not anaerobic bacteria)
Inhibit protein synthesis by binding to 30S ribosomal subunit
Bacteriostatic (may reach bacteriocidal levels)
Ex. Gentamicin
“
Beta-lactams
“Beta-lactam
Gram positive and negative bacteria (may vary with individual antibiotic)
Inhibit cell wall synthesis by binding enzymes involved in peptidoglycan production
Bacteriocidal
Ex. Cefazolin, Imipenem, Ampicillin, Piperacillin/Tazobactam combo (ties up beta lactamases so other antimicrobial can exert it’s affect)
”
Glycopeptides
“Glycopeptides
Gram positive and negative bacteria (topical treatment)
Inhibit bacteria cell wall synthesis, but does not bind to PBPs
Bacteriocidal
Ex. Vancomycin
“
Fluoroquinolones
“Fluoroquinolones
Gram positive and gram negative bactia (may vary with individual antibiotic)
Inhibit DNA synthesis by binding DNA gyrases
Bacteriocidal
Ex. Levofloxican
“
Azoles
"Azoles Fungi (primarily yeast) Disrupts the fungal cell membrane by interfering with the synthesis of ergosterol. Fungicidal Ex. Fluconazole"
Oxazolidinones
“Oxazolidinones
Wide variety of gram positive bacteria, including those resitant to other microbial classes
Bind to 50S ribosomal subunit to interfere with initiation of protein synthesis
Bacteriostatic
Ex. Linezolid”
Macrolide examples
Erythrocymin
Aminoglycosides examples
Gentamicin
Beta-lactams examples
Cefazolin, Imipenem, Ampicillin, Piperacillin/Tazobactam combo
Glycopoptide examples
Vancomycin
Fluoroquinolones examples
Levofloxacin
Azoles example
Fluconazole
Oxazolidinones example
Linezolid
Macrolide spectrum
Gram positive bacteria