Antimicrobials Flashcards

1
Q

Macrolides

A
Macrolides
Gram positive bacteria
Protein synthesis is inhibited by drug binding to receptors on the 50S ribosomal subunit and subsequent disruption of the growing peptide chain
Bacteriostatic
Ex: Erythromycin
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2
Q

Aminoglycosides

A

“Aminoglycoside
Gram positive and negative bacteria (not anaerobic bacteria)
Inhibit protein synthesis by binding to 30S ribosomal subunit
Bacteriostatic (may reach bacteriocidal levels)
Ex. Gentamicin

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3
Q

Beta-lactams

A

“Beta-lactam
Gram positive and negative bacteria (may vary with individual antibiotic)
Inhibit cell wall synthesis by binding enzymes involved in peptidoglycan production
Bacteriocidal
Ex. Cefazolin, Imipenem, Ampicillin, Piperacillin/Tazobactam combo (ties up beta lactamases so other antimicrobial can exert it’s affect)

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4
Q

Glycopeptides

A

“Glycopeptides
Gram positive and negative bacteria (topical treatment)
Inhibit bacteria cell wall synthesis, but does not bind to PBPs
Bacteriocidal
Ex. Vancomycin

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5
Q

Fluoroquinolones

A

“Fluoroquinolones
Gram positive and gram negative bactia (may vary with individual antibiotic)
Inhibit DNA synthesis by binding DNA gyrases
Bacteriocidal
Ex. Levofloxican

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6
Q

Azoles

A
"Azoles
Fungi (primarily yeast)
Disrupts the fungal cell membrane by interfering with the synthesis of ergosterol.
Fungicidal 
Ex. Fluconazole"
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7
Q

Oxazolidinones

A

“Oxazolidinones
Wide variety of gram positive bacteria, including those resitant to other microbial classes
Bind to 50S ribosomal subunit to interfere with initiation of protein synthesis
Bacteriostatic
Ex. Linezolid”

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8
Q

Macrolide examples

A

Erythrocymin

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9
Q

Aminoglycosides examples

A

Gentamicin

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10
Q

Beta-lactams examples

A

Cefazolin, Imipenem, Ampicillin, Piperacillin/Tazobactam combo

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11
Q

Glycopoptide examples

A

Vancomycin

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12
Q

Fluoroquinolones examples

A

Levofloxacin

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13
Q

Azoles example

A

Fluconazole

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14
Q

Oxazolidinones example

A

Linezolid

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15
Q

Macrolide spectrum

A

Gram positive bacteria

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16
Q

Aminoglycosides spectrum

A

Gram positive and negative bacteria (not anaerobes)

17
Q

Beta-lactams spectrum

A

Gram positive and negative bacteria (varies)

18
Q

Glycopoptide spectrum

A

Gram positive bacteria (topical treatment)

19
Q

Fluoroquinolones spectrum

A

Gram positive and negative bacteria (varies)

20
Q

Azoles spectrum

A

Fungi (primarily yeast)

21
Q

Oxazolidinones spectrum

A

Wide variety of gramm positive bacteria (including those resistant to other antimicrobial classes)

22
Q

Name the bacteriostatic antimicrobials

A

Erythromycin, Gentamicin, Linezolid