Antimicrobials Flashcards
MOA of PCNs
bind PBPs–> inhib. transpeptidation–> inhib. crosslinking of bacterial cell walls
Mech. of Resistance for PNCs
penicillinases (B lactamases); structural change in PBP, change in porin structure
how do you treat MRSA?
vancomycin
how do you treat syphillis?
PCN G or V
what are the narrow spectrum PCNs?
PCN G and V
*B lactamase sensitive
List the lactams
PCNs, cephalosporins, imipenem, meropenem, aztreonam
what are the very narrow spectrum PCNs? what do they treat?
methicillin, nafcillin, oxacillin
staph aureus (not MRSA)
*B lactamase resistant
what are the broad spectrum PCNs?
amoxicillin, ampicillin
tx: gram + cocci, not staph, listeria, E. coli, H influenza, borrelia, H. pylori
* B lactamase sensitive
what are the extended spectrum PCNs?
ticarcillin, piperacillin, azlocillin
tx: gram neg rods, pseudomonas
* B lactamase sensitive
* *synergy with aminoglycosides
how are most PCNs excreted?
kidney
*dose reduction in kidney disease
What two PCNs are NOT excreted in the kidney?
nafcillin, oxacillin (bile excretion)
If a person is allergic to one PCN, can you give them a different one?
NO, assume allergy to all PCNs
What is the most unique side effect of PCNs?
Jarish-herxheimer rxn - when tx syphilis
What part of a PCN tends to cause hypersensitivity?
sulfur group
What is a side effect of methicillin?
interstitial nephritis
What is a common side effect of PCNs?
GI distress
how do you enhance PCN activity?
add Clavulanic acid or sulbactam
they are B lactamase inhib.
what drug increases PCN and cephalosporin concentration?
probenecid
What is the MOA of cephalosporins?
same as PCNs: bind PBPs–> inhib. transpeptidation–> inhib. crosslinking of bacterial cell walls
same resistance mech too.
first generation cephalosporins
cefazolin
cePHalexin
what are first generation cephalosporins used for?
surgical prophylaxis gram + E. coli klebsiella proteus
second generation cephalosporins
cefotetan, cefaclor,
cefuroxime–> crosses BBB
What are second generation cephalosporins used for?
gram neg.
third gen. cephalosporins
ceftriaxone, cefotaxime, cefdinir, cefixime, cefoperazone
what do you use third gen. cephalosporins for?
empirical tx of sepsis and meningitis
NO ACTIVITY AGAINST LAME: listeria, atypicals, MRSA, enterococci
How do you treat listeria?
amoxicillin
How do you treat atypicals?
macrolides or tetracyclines
How do you treat enterococci?
amoxicillin with aminoglycosides
4th gen. cephalosporins
cefepime IV only!
- wider spectrum
- B lactamase resistant
- *enters CNS
What is the mode of excretion for most cephalosporins?
Kidney
What cephalosporins are not excreted through the kidney?
cefoperazone, ceftriaxone –> bile
Cephalosporin Side Effects
hypersensitivity, GI distress, Disulfiram-like effect
What drug should you use if a pt is allergic to cephalosporins?
macrolides (gram+), or aztreonam (gram-)
MOA of imipenem and meropenem?
same as PCN but resistant to B lactamases
What doe you use imipenem and meropenem for?
gram + cocci, gram - rods, empiric use in nosocomial infections
What drug must you give with imipenem? Why?
cilastatin
prevent kidney from metabolizing it too quickly
SE of imipenem and meropenem?
GI distress, drug fever, CNS
**1/2 of pts have seizures with imipenem
MOA for aztreonam? Use? SE?
same as PCNs + B lactamase RESISTANT
ONLY IV
use: gram neg. rods
**no cross allergenicity with cephalosporins and PCNs
MOA vancomycin
binds d-ala-d-ala muramyl pentapeptide–> blocks transglycosylation–> prevents elongation of peptidoglycan cell wall
What do you use vancomycin for?
MRSA
enterococci
c. diff
What is the first line tx for C. difficile?
metronidazole
What are VRSA and VRE microbes? how do they develop resistance?
vancomycin resistant staph aureus
vancomycin resistant enterococci
*change in muramyl pentapeptide target to d-lactate
how do you treat VRSA and VRE?
linezolid and streptogramins
How is vancomycin delivered?
IV
orally only for colitis
SE of vancomycin?
Red man syndrome (histamine induced vasodilation)
ototoxicity
nephrotoxicity
MOA of aminoglycosides
inhibits initiation of protein synthesis (30S subunit)–> BACTERIOSTATIC
can also cause misreading of genetic code-> BACTERIOCIDAL