Antimicrobial Pharm

Question 1

Amphotericin B MOA

Answer 1

-creates pores in the fungal membrane that are lined by hydrophilic groups

Question 2

Aminoglycoside MOA

Answer 2

• cause mRNA misreading -> wrong amino acid in peptide-> nonfunctional/toxic protein
• breaks down polysomes to nonfunctional monsomes

Question 3

Protease inhibitor (-avir) side effect

Answer 3

-lipodystrophy

Question 4

What bacteria does Fluoroquinolones treat?

Answer 4

1. Pseudomonas
2. GN UTI bacteria
3. Neiserria
4. Bacillius anthrax

Question 5

Fluoroquinolone side effect

Answer 5

1. arthropathy in growing cartilage (reversible)

2. potential TENDON RUPTURE

Question 6

What treats yeast in AIDs patients?

Answer 6

ECHINOCADINS

Question 7

Causes a high incidence of skin rash

Answer 7

Ampicillin

Question 8

What would you use to treat acute Staph infections?

Answer 8

Oxacillin

Question 9

Which penicillin has the longest action duration?

Answer 9

Penicillin G

Question 10

Rifampin MOA

Answer 10

1. inhibits RNA synthesis

2. has LOW TOXICITY

Question 11

Isoniazide side effect

Answer 11

-age-related toxicity

Question 12

How can you cause neuromuscular blockage/curare-like muscle paralysis?

Answer 12

Aminogylcoside Overdose

Question 13

Fluoroquinolone MOA

Answer 13

-inhibits TOPOISOMERASE IV (4), which separates chromosome strands during replication

Question 14

Metronidazole side effect

Answer 14

1. black coating on tongue
2. metallic taste
3. Leucopenia

Question 15

Amphotericin side effect

Answer 15

• INFUSION RELATED RXN

* give STEROID PREDOSE and administer amphotericin again

Question 16

Chloramphenicol MOA

Answer 16

-inhibits protein synthesis at translation

Question 17

Flucytosine MOA

Answer 17

-causes incorrect nucleotide insertion in fungal DNA -> THYMIDYLATE SYNTHETASE inhibition

Question 18

Telithromycin side effect

Answer 18

1. hepatitis
2. liver failure

*created to overcome erythromycin resistance

Question 19

Which antimicrobials INHIBIT CELL-WALL SYNTHESIS?

Answer 19

1. Penicillin
2. Cephalosporins
3. Imipenem
4. Aztreonam
5. Vancomycin

Question 20

Name the antimicrobials that INHIBIT PROTEIN SYNTHESIS.

Answer 20

1. Aminoglycoside
2. Chloramphenicol
3. Macrolides
4. Tetracyclines
5. Streptogramins
6. Linezolid

Question 21

Which antimicrobials INHIBT DNA REPLICATION/TRANSCRIPTION?

Answer 21

1. Fluoroquinolones

2. Rifampin

Question 22

Name the antimicrobials that INHIBIT NUCLEIC ACID SYNTHESIS.

Answer 22

1. Trimethoprim

2. Flucytosine

Question 23

Name the antimicrobials that INHIBIT FOLIC ACID SYNTHESIS.

Answer 23

1. Sulfonamides
2. Trimethoprim
3. Pyrimethamine

Question 24

Which antimicrobials DISRUPT THE FUNCTION OF THE FUNGAL CELL MEMBRANE?

Answer 24

1. Azole

2. Polyene

Question 25

TMP-SMX SD

Answer 25

1. Steven-Johnson Syndrome
2. Hemolytic anemia
3. Kernicterus

Question 26

Vancomycin SD

Answer 26

1. “Red Man Syndrome”
2. Otoxicity
3. Nephrotoxicity