Antimicrobial Efficacy Flashcards
1
Q
Efficacy is a complicated concept
A
the interaction of an antimicrobial and a pathogen happens in a complex matrix of disease characteristics
Clinical resolution can be dependent on a lot more than just antimicrobial-pathogen interaction
Antimicrobials can also have other significant effects besides action on the pathogen
2
Q
Disease triad
A
3
Q
How is efficacy Demonstrated?
A
- Against negative controls in naturally occurring disease
- primarily food animals
- Pivotal and private
- Non-inferiority studies agianst approved antimicrobials
- Generic approval matiching a generic drug to the substantial evidence of efficacy for an approved drug
4
Q
Foundation Question
A
Can we monitor drug efficacy with treatment outcome records?
5
Q
Ceftiofur Crystalline free acid for Equine Pneumonia
A
6
Q
ARR
A
Attributable Reduction in Risk
7
Q
NNT
A
Number Needed to Treat to make a difference in one animal according to the protocol criteria
