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Antimicrobial compounds > antimicrobial compounds > Flashcards

antimicrobial compounds Flashcards

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Organic Chemistry 101 flashcards
1
Q

Cefazolin

A

1th generation cephalosporin: used for surgical prophylaxis

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2
Q

Cefuroxim

A

2th generation cephalosporin: Gram neg/pos activity : used for infections unknown orgin

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3
Q

Ceftriaxon

A

3th generation cephalosporin: Broader activity

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4
Q

Cefotaxim

A

3th generation cephalosporin: Broader activity

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5
Q

Ceftazidimime

A

3th generation cephalosporin: Broader activity

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6
Q

Cefeprime

A

4th generation cephalosporin: increased gram activity. spectrum similar to 3th generation

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7
Q

ceftaroline

A

5th generation cephalosporin: active against MRSA

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8
Q

Auremycine

A

Natural compound tetracycline: never intended as medicin

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9
Q

Doxycycline

A

2th generation tetracycline

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10
Q

Penicillin

A

Against streptococci: Blocks peptidoglycan biosynthese

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11
Q

Thienamycin

A

Natural compound carbapenem

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12
Q

3 classes beta lactam

A

Penicillin/ cephalosporin/ carbapenem

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13
Q

Glycopeptide

A

against cell evelopp

against gram+ and anaeroben

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14
Q

Vancomycin

A

work at cell enveloppe same glycopeptide

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15
Q

teicoplanin

A

work at cell enveloppe same glycopeptide

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16
Q

Colistin

A

Permeabilize bacterial cell membraan, gram negatives

17
Q

polymycin E

A

permebilize bacterial cell membraan gram negatives

18
Q

Amino glycosides

A

changes 30s portion coad on mRNA read incorrect. O2 dependent

19
Q

Gentamicin

A

changes 30s portion coad on mRNA read incorrect. O2 dependent

20
Q

Tobomycin

A

changes 30s portion coad on mRNA read incorrect. O2 dependent

21
Q

Streptomycin

A

changes 30s portion coad on mRNA read incorrect. O2 dependent

22
Q

Tetracycline

A

Interfere with tRNA - mRNA ribosome complex

Resistant to efflux mechanism

23
Q

Macrolides

A

Bind 50s prevrents translocation movement of ribosome over mRNA, against grampos/neg, mycobacteria

24
Q

Erythromycin

A

Bind 50s prevrents translocation movement of ribosome over mRNA, against grampos/neg, mycobacteria

25
Q

Clarithromycin

A

Bind 50s prevrents translocation movement of ribosome over mRNA, against grampos/neg, mycobacteria

26
Q

Azithromycin

A

Bind 50s prevrents translocation movement of ribosome over mRNA, against grampos/neg, mycobacteria

27
Q

Clindamycin

A

Bind 50s prevrents translocation movement of ribosome over mRNA, against grampos/neg, mycobacteria. Against parasites

28
Q

Chloromphericol

A

Bind 50s and inhibits formation peptide bond

29
Q

Fluoroquinolone

A

DNA gyrase inhibitor: complete synthetic

30
Q

Ciprofloxin

A

DNA gyrase inhibitor: complete synthetic against gram neg and some pos

31
Q

Levoflaxin

A

DNA gyrase inhibitor: complete synthetic, better gram pos

32
Q

Moxifloxacin

A

DNA gyrase inhibitor: complete synthetic, better anearoob

33
Q

Cotrimoxazole

A

Trimethoprim + sulfamethoxazol: synergistic against folic acid biosynthesis

34
Q

Metronidazole

A

Prodrug: block DNA synthesis. against anearoob bacteria and protozoa.
resistance rare
Antabuse reaction

35
Q

Nitrofurantoin

A

inhibit general metabolism: bind enzymes kreb cycle

36
Q

Fosfomycine

A

inhibit general metabolism: disrupt bacterial cell wall synthese

37
Q

Line zolid

A

Block initiation protein production: works against VRE

Antimicrobial compounds (1 decks)

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