antimicrobial compounds

Question 1

Cefazolin

Answer 1

1th generation cephalosporin: used for surgical prophylaxis

Question 2

Cefuroxim

Answer 2

2th generation cephalosporin: Gram neg/pos activity : used for infections unknown orgin

Question 3

Ceftriaxon

Answer 3

3th generation cephalosporin: Broader activity

Question 4

Cefotaxim

Answer 4

3th generation cephalosporin: Broader activity

Question 5

Ceftazidimime

Answer 5

3th generation cephalosporin: Broader activity

Question 6

Cefeprime

Answer 6

4th generation cephalosporin: increased gram activity. spectrum similar to 3th generation

Question 7

ceftaroline

Answer 7

5th generation cephalosporin: active against MRSA

Question 8

Auremycine

Answer 8

Natural compound tetracycline: never intended as medicin

Question 9

Doxycycline

Answer 9

2th generation tetracycline

Question 10

Penicillin

Answer 10

Against streptococci: Blocks peptidoglycan biosynthese

Question 11

Thienamycin

Answer 11

Natural compound carbapenem

Question 12

3 classes beta lactam

Answer 12

Penicillin/ cephalosporin/ carbapenem

Question 13

Glycopeptide

Answer 13

against cell evelopp

against gram+ and anaeroben

Question 14

Vancomycin

Answer 14

work at cell enveloppe same glycopeptide

Question 15

teicoplanin

Answer 15

work at cell enveloppe same glycopeptide

Question 16

Colistin

Answer 16

Permeabilize bacterial cell membraan, gram negatives

Question 17

polymycin E

Answer 17

permebilize bacterial cell membraan gram negatives

Question 18

Amino glycosides

Answer 18

changes 30s portion coad on mRNA read incorrect. O2 dependent

Question 19

Gentamicin

Answer 19

changes 30s portion coad on mRNA read incorrect. O2 dependent

Question 20

Tobomycin

Answer 20

changes 30s portion coad on mRNA read incorrect. O2 dependent

Question 21

Streptomycin

Answer 21

changes 30s portion coad on mRNA read incorrect. O2 dependent

Question 22

Tetracycline

Answer 22

Interfere with tRNA - mRNA ribosome complex

Resistant to efflux mechanism

Question 23

Macrolides

Answer 23

Bind 50s prevrents translocation movement of ribosome over mRNA, against grampos/neg, mycobacteria

Question 24

Erythromycin

Answer 24

Bind 50s prevrents translocation movement of ribosome over mRNA, against grampos/neg, mycobacteria

Question 25

Clarithromycin

Answer 25

Bind 50s prevrents translocation movement of ribosome over mRNA, against grampos/neg, mycobacteria

Question 26

Azithromycin

Answer 26

Bind 50s prevrents translocation movement of ribosome over mRNA, against grampos/neg, mycobacteria

Question 27

Clindamycin

Answer 27

Bind 50s prevrents translocation movement of ribosome over mRNA, against grampos/neg, mycobacteria. Against parasites

Question 28

Chloromphericol

Answer 28

Bind 50s and inhibits formation peptide bond

Question 29

Fluoroquinolone

Answer 29

DNA gyrase inhibitor: complete synthetic

Question 30

Ciprofloxin

Answer 30

DNA gyrase inhibitor: complete synthetic against gram neg and some pos

Question 31

Levoflaxin

Answer 31

DNA gyrase inhibitor: complete synthetic, better gram pos

Question 32

Moxifloxacin

Answer 32

DNA gyrase inhibitor: complete synthetic, better anearoob

Question 33

Cotrimoxazole

Answer 33

Trimethoprim + sulfamethoxazol: synergistic against folic acid biosynthesis

Question 34

Metronidazole

Answer 34

Prodrug: block DNA synthesis. against anearoob bacteria and protozoa.
resistance rare
Antabuse reaction

Question 35

Nitrofurantoin

Answer 35

inhibit general metabolism: bind enzymes kreb cycle

Question 36

Fosfomycine

Answer 36

inhibit general metabolism: disrupt bacterial cell wall synthese

Question 37

Line zolid

Answer 37

Block initiation protein production: works against VRE