Antimicrobial Chemotherapy Flashcards

1
Q

Which antibiotic can inhibit peptidoglycan synthesis?

a) penicillin
b) erythromycin
c) ciprofloxacin

A

a)penicillin

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2
Q

Name 2 glycopeptides

A

vancomycin and teicoplanin

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3
Q

Which antibiotic is commonly known to cause C. diff

a) gentamicin
b) daptomycin
c) cephalosporins

A

Cephalosporins

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4
Q

What do glycopeptides target?

a) protein synthesis
b) assembly of peptidoglycan precursor
c) purine synthesis

A

b)assembly of peptidoglycan precursor

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5
Q

Which gram positive cocci is resistant against gentamicin?

A

streptococcus

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6
Q

What do macrolides and tetracylines target?

a) peptidoglycan synthesis
b) DNA synthesis
c) protein synthesis

A

c)protein synthesis

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7
Q

What 5 antibiotic classes target protein synthesis?

A
aminoglycosides
macrolides
tetracyclines
oxazolidinone
cyclic lipopeptide
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8
Q

What is given alongside trimethoprim in the treatment of UTI/chest infections?

A

sulphamethoxazole

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9
Q

Which protein synthesis inhibitor targets gram negative bacteria?

a) clarithromycin
b) teicoplanin
c) gentamicin

A

c)gentamicin

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10
Q

Which group of antibiotics target topoisomerase in inhibiting DNA synthesis?

a) fluroquinolones
b) cyclic lipopeptides
c) tertracylines

A

a)fluroquinolones

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11
Q

Which antibiotic can be used to replace penicillin in gram positive infection?

a) marcolides (erythromycin and clarithromycin)
b) oxazolidinones
c) ciprofloxacin

A

a)macrolides

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12
Q

What type of bacteria is levofloxacin used to treat?

a) gram negative
b) gram positive
c) curved bacilli

A

b)gram positive

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13
Q

Which protein synthesis inhibitors are effective against MRSA?

A

linezolid and daptomycin

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14
Q

Which polyene is used for serious fungal infection?

a) amphotericin B
b) nystatin
c) terbinafine

A

a)amphotericin B

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15
Q

What do Azoles target?

a) ergosterol synthesis
b) glucan polysaccharide synthesis
c) protein synthesis

A

a)ergosterol synthesis

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16
Q

How is nystatin administered?

a) topical
b) oral
c) IV

A

a)topical

17
Q

What is fluconazole an example of?

a) azole
b) allylamines
c) echinocandins

A

a)azole

18
Q

What anti fungal is used for candida and aspergillum species?

a) allylamines
b) polyenes
c) echinocandins

A

c)echinocandins

19
Q

What is terbinafine?

a) polyenes
b) allylamine
c) azole

A

b)allylamine

20
Q

Which anti fungal binds erogesterol and increases membrane permeability?

a) azoles
b) echinocandins
c) polyenes

A

c)polyenes

21
Q

What are caspofungin, mycafungin and anidulafungin?

a) polyenes
b) allylamines
c) echinocandins

A
22
Q

What does aciclovir target?

a) HSV and VZV
b) HSV alone
c) VZV alone

A

a)herpes simplex and varicella zoster viruses

23
Q

When should zanamivir be given in relation to onset of symptoms?

a) within 24 hours
b) within 48 hours
c) within 12 hours

A

b)within 48 hours

24
Q

What is used in combination to treat HIV?

a) nevirapine and saquinavir
b) zanamivir and oseltamivir
c) famiclovir and valaciclovir

A