Antimetabolites and Inhibitors of Nucleic Acid Synthesis

Question 1

Quinolones

Answer 1

One of the most widely used class-inhibit bacterial DNA gyrase (ciproflaxacin, levofloxacin, moxifloxacin)

Question 2

Rifampin and Rifabutin

Answer 2

Binds DNA dependent RNA polymerase thusly inhibiting RNA synthesis
Rifampin= M tuberculosis
Rifabutin= M. avium

Question 3

Metronidazole

Answer 3

Produces cytotoxic compounds that disrupt host DNA

Question 4

Sulfonamides

Answer 4

prevent synthesis of folic acid

Question 5

Trimethoprim

Answer 5

inhibits dihydrofolate reductase

Question 6

Dapsone

Answer 6

antifolate