Antimetabolites Flashcards
1
Q
What are the antimetabolites
A
1) sulfaonamides
2) trimethoprim
2
Q
What is the most common sulfonamide
A
Sulfamethoxazole/ trimethoprim (bactrim)
3
Q
Uses of sulfonamides
A
1) Cellulitis and UTI
2) (he just wrote GRAM +)
- but also MRSA and MSSA
4
Q
Contraindications of sulfonamides
A
History of drug induce immune thrombocytopenia
5
Q
ADR sulfonamides
A
1) Hyperkalemia - d/t blocked Na channel in the distal nephron and this inhibits K secretion (Potentially fatal)
2) hypersensitivity reactions- - delayed, steven johnson syndrom (severe rash)
- immediate - rash/angioedema/anaphylaxis
