Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CR2 > Antimalarial Drugs > Flashcards

Antimalarial Drugs Flashcards

1
Q

List the three groups of antimalarial drugs.

A

Group I: chloroquine, quinine, fansidar, artemisinin compounds, tetracyclines (work for erythrocytic stage asexual)
Group II: proguanil, atovaquone (work for primary hepatic stage and erythrocytic stage asexual)
Group III: primaquine (work for hepatic stage primary and latent)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Goals of treatment in malaria

A

Cure
Prophylaxis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Two types of cure in malaria?

A
  1. Clinical cure: eliminate blood stage parasites (falciparum)
  2. Radical cure: eliminate blood stage and dormant liver stage parasite (vivax and ovale)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Two types of prophylaxis treatment in malaria?

A
  1. Suppressive: blood (falciparum)
  2. Causal: blood & tissue (vivax & ovale)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which species of parasites cause relapse and which cause symptoms?

A

Relapse: dormant liver stage parasite (vivax & ovale)
Symptoms: blood stage parasite (falciparum, vivax & ovale)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Antimalarial drugs

A

Chloroquine
Quinine
Artemisinin compound (ACT)
Fansidar (sulfadoxin+ pyrimethamine)
Tetracycline & doxycycline
Proguanil
Atovaquone
Primaquine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which drugs are the first line therapy in malaria?

A

Quinine (cerebral malaria, severe & CQ resistant falciparum)
Artemisinin compounds (ACT) :falciparum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which drug is only effective in primary and latent hepatic stages but no effects on asexual erthrocyctic form?

A

Primaquine
Contraindication in G6PD deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Chloroquine is used for

A

Clinical cure: vivax & ovale
Clinical & radical cure for CQ sensitive falciparum
Prophylaxis: CQ sensitive

*primarily target blood stage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Quinine brings about what adverse effects

A

Black water fever
TRIAD: cinchonism, hypoglycaemia, hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Artemisinin compound (ACT) is not use alone but with?

A

Lumefantrine or mefloquine or quinoline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which antimalarial drugs have the contraindication of G6PD deficiency?

A

Chloroquine
Primaquine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which antimalarial drugs have no effects on primary and latent phase (liver)?

A

Chloroquine
Quinine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which antimalarial drugs are effective against falciparum?

A

Artemisinin compounds + quinoline/ lumefantrine/ mefloquine
Fansidar+ quinine/ ATC
Proguanil + atovaquone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which antimalarial drug cannot act as prophylaxis? Which can?

A

Fansidar cannot
Primaquine can

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which antimalarial drug is effective in the radical cure and prevention of relapse in vivax and ovale and also provide prophylaxis?

A

Primaquine

17
Q

Which antimalarial drugs cannot be used alone?

A

Fansidar
Tetracycline/doxycycline
Proguanil
Atovaquone

18
Q

Life cycle of malaria parasite

A
  1. sporozoite
  2. hepatic/tissue stages (PERSISTENT INFXN/ RELAPSE)
    -primary
    -latent falciparum no latent phase
  3. erythrocytic asexual (CLINICAL ILLNESS)
  4. erythrocytic sexual (TRANSMISSION)

CR2 (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions