Antilipemic agents

Question 1

What are the names of HMG-CoA

Answer 1

“Statins”. Atorvastatin , simvastatin, lovastatin, pravastatin, rosuvastatin, fluvastatin, pitavastatin

Question 2

Which of the Statins is not recommended for asian populations . and why ?

Answer 2

Rosuvastatin increae risk for myopathy it should be avoided or prescribed in smaller doses

Question 3

What is the pharmocological action of statins

Answer 3

to decrease the LDL VDL and increase HDL – other benifits are promotion of vasodilation through removal of plaque site decrease in thrombo embolism and decrease risk for atrial fibrilation

Question 4

Primary use of statins are

Answer 4

hyper cholesterolemia

Question 5

Common complications or Side effects of Statins

Answer 5

hepatotoxicity, Myopathy

Question 6

Due to the two common side effects what lab levels would you need to monitor with Statins?

Answer 6

hepatoxicity, Ast, Alt, lab / Myopathy CK CPK lab if ck levels are elevated medication might be discontinued

Question 7

Myopathy manifestations

Answer 7

muscle aches pains and tenderness can progress to myositis or rhabdomyolysis

Question 8

in patients with sever kidney impairment

Answer 8

reduce the dose

Question 9

Pregnancy risk category

Answer 9

X

Question 10

Contrindicated in pts who

Answer 10

have a liver disorder or are breast feeding

Question 11

These medications increase the risk of myopathy

Answer 11

fibrates, gemfbirozil, fenofibrate, ezetimibe

Question 12

Statins are administered at what time of day

Answer 12

at night - because Cholesterol synth at night

Question 13

theses medications increase levels of statins

Answer 13

because they supress CY3A4 erythromycin,ketoconazole hiv protase inhibitors amiodarone ctclosporine increase levels

Question 14

Grape fruit juice

Answer 14

also supresses CY3A4 increases levels of statins

Question 15

with statins you are prone to

Answer 15

fatigue , and wrinkles due to a decrease in co enzyme 10 advise pt to take COQ 10 – co enzyme 10