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Nursing Pharmacology > Antihypertensives > Flashcards

Antihypertensives Flashcards

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1
Q

How does Renin-Angiotensin-Aldosterone System (RAS) work?

A
  • Kidneys release Renin
  • Liver releases Angiotensinogen and combines with Renin to make Angiotensin I
  • Angiotensin I moves into the lungs and combines with ACE to make Angiotensin II
  • Angiotensin II causes arteriolar vasoconstriction (^BP) and Kidneys release of Aldosterone resulting in tubular Na+, Cl- reabsorption and K+ excretion and H2O retention, increased sympathetic system activity, and release of ADH from the pituitary gland which causes the collecting duct to reabsorb H2O
  • H2O and NaCl retention increases circulating volume. Perfusion of the juxtaglomerular apparatus increases negatively effecting the release of Renin.
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2
Q

Angiotensin-converting enzyme inhibitors (ACE) end in?

A

pril

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3
Q

Angiotensin-converting enzyme inhibitors (ACE) examples?

A

Lisinopril

Captopril

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4
Q

Angiotensin-converting enzyme inhibitors (ACE) action?

A

Prevents Angiotensin II production causes vasodilation and secretion of Na+ and H2O and retention of K+

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5
Q

Angiotensin-converting enzyme inhibitors (ACE) indication?

A
  • Hypertension
  • Diabetic Nephropathy
    • Used with extreme caution in Heart Failure patients
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6
Q

Angiotensin-converting enzyme inhibitors (ACE) adverse effects?

A
  • Kidney damage
  • Hypotension
  • Cough
  • Hyperkalemia
  • Angio Edema
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7
Q

Angiotensin-converting enzyme inhibitors (ACE) contraindications?

A
  • Hx angioedema

- pregnancy

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8
Q

Angiotensin-converting enzyme inhibitors (ACE) Interactions?

A
  • Antihypertensive drugs
  • Diuretics
  • K+ supplements
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9
Q

Angiotensin-converting enzyme inhibitors (ACE) patient teaching?

A
  • Report persistant cough
  • S/s hypotension (dizziness, light-headedness…)
  • Stand slowly
  • S/s angioedema
  • Talk to doctor if you plan to get pregnant or are pregnant
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10
Q

Angiotensin II Receptor Blockers (ARBS) end in?

A
  • sartan
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11
Q

Angiotensin II Receptor Blockers (ARBS) examples?

A
  • Losartan

- Valsartan

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12
Q

Angiotensin II Receptor Blockers (ARBS) action?

A
  • Blocks angiotensin II receptors causing vasodilation, K+ retention
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13
Q

Angiotensin II Receptor Blockers (ARBS) indications?

A
  • Hypertension
  • Nephropathy
  • Heart Failure
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14
Q

Angiotensin II Receptor Blockers (ARBS) contraindications?

A
  • pregnancy
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15
Q

Angiotensin II Receptor Blockers (ARBS) adverse effects?

A
  • Angioedema
  • Renal dysfunction
  • Hypotension
  • Hyperkalemia
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16
Q

Angiotensin II Receptor Blockers (ARBS) interactions?

A
  • Other antihypertensive drugs
17
Q

Angiotensin II Receptor Blockers (ARBS) patient teaching?

A
  • Report persistant cough
  • S/s hypotension (dizziness, light-headedness…)
  • Stand slowly
  • S/s angioedema
  • Talk to doctor if you plan to get pregnant or are pregnant
18
Q

Renin inhibitor examples?

A
  • Aliskiren
19
Q

Renin inhibitor action?

A
  • Inhibits Renin production/release causing vasodilation
20
Q

Renin inhibitor adverse effects?

A
  • Angioedema
  • renal dysfunction
  • Hypotension
  • Hyperkalemia
21
Q

Renin inhibitor indication?

A
  • Hypertension
  • Nephropathy
  • Heart Failure
22
Q

Renin inhibitor contraindications?

A
  • pregnancy
  • Angioedema
  • hypotension

Nursing Pharmacology (2 decks)

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