Antihypertensive MOA

Question 1

Beta blockers

Answer 1

Bind to beta adrenoceptors
Block the binding of norepinephrine and epinephrine
Inhibit normal sympathetic effects

Question 2

1st gen beta blockers

Answer 2

Non selective
Block both b1 and b2 adrenoceptors

Question 3

2nd Gen beta blockers

Answer 3

Cardioselective
Relatively selective for b1 adrenoceptors

Question 4

3rd gen beta blockers

Answer 4

Possess vasodilator actions through blockade of vascular a adrenoceptors

Question 5

Alpha 1 selective adrenoceptor blockers / Alpha 1 antagonists

Answer 5

Selectively block a1 adrenoceptors

Question 6

Vasodilators

Answer 6

Relax smooth muscles of the arterioles
Decrease systemic vascular resistance

Question 7

Calcium channel blockers

Answer 7

Inhibition of calcium influx into arterial smooth muscle cells

Question 8

ACE inhibitors

Answer 8

Inhibit angiotensin-converting enzyme

Question 9

Angiotensin receptor blocker (ARB)

Answer 9

Competitive inhibitors of angiotensin at its receptors
Block AT1 angiotensin receptors

Question 10

Renin inhibitor

Answer 10

Inhibits enzyme activity of renin

Question 11

Aldosterone receptor inhibitors

Answer 11

Block aldosterone receptor in renal collecting tubule

Question 12

Centrally acting sympathoplegic drugs

Answer 12

Activate A2 adrenoceptor

Question 13

Postganglionic sympathetic nerve terminal

Answer 13

Prevent normal physiologic release of norepinephrine from postganglionic sympathetic neurons

Question 14

Ganglion blocking agent

Answer 14

Nicotinic blockers that act on the ganglia