Antihypertenives and diuretics ppt Flashcards
what converts renin into AT I
angiotensinogen
what in the RAAS is a huge player in B/P management and is a huge vasoconstrictor?
AT II
ACEi’s are used for treatment of what?
htn and CHF
what drugs are one of the biggest mediators for intraoperative hypotension
ACEi’s
and ARBS
ACEi’s MOA
Inhibits ACE peptidyl dipetase
this directly interferes with the conversion of ATI to ATII
what is apowerful vasopressor that also stimulates the release of norepinephrine and aldosterone
ATII
what causes the cough associated with ACEi’s
the breakdown of bradykinins
Frequent SE of ACEi’s
Cough
hypotension
Rash
ARF
Angioedema
Increased fetal mortality rate
Angiotensin receptor blockers (ARBs) MOA
blocks the angiotensin receptor
interferes with binding of ATII receptor, preventing the formation of ATII
what drugs are ARBs
“sartins”
what is the main difference b/t ACEi’s and ARBs
ARBs do ot have the kinase mediated cough
what is an example of an osmotic diuretic
Mannitol
basic way mannitol (osmotic diuretics work)
increases osmotic gradient and prevents fluid reabsorption
(pulls in more fluids)
Are thiazide diuretics K+ sparing?
Nope
thiazide diuretic increase the excretion of what
Na+ and K+
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thiazide diuretics effect where in the kidney to interfere with the normal electrolyte reabsorption
distal renal tubular
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where do diuretic work
Carbonic anhydrase inhibitors
Osmotic diuretcs
loop diuretics
Thiazide diuretics
K+ sparing diuretics
Carbonic anhydrase inhibitors- Proximal convoluted tubule
Osmotic diuretcs- proximal convoluted tubule
loop diuretics- ascending loop
Thiazide diuretics- distal convoluted tubule
K+ sparing diuretics- cortical collecting ducts
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Loop diuretics
ex
action
where they work
lasix
inhibit reabsorption of Na+ and Cl-
ascending loop of henle
what is different about bumex from lasix since both loop diuretics
bumex works in both ascending and descending loop
done!!
yeah
