Antihelminthics Flashcards

1
Q

What are the 3 main helminthic groups?

Which group attacks the GI system?

A

Nematodes * GI system
Trematodes
Cestodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the main nematodes that we are concerned with?

A

Pinworms (Enterobiasis)
Hookworm
River Blindness
Guinea Worm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the most common worm infection in the US?

A

Pinworm - Enterobius vermicularis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Who is most likely to get a pinworm infection?

How is it transmitted?

A

Children, institutionalized people, house-hold members of infected people
Fecal-oral route

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the symptoms of a pin worm infection?

A

Anal itching - sleep disturbance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How do you treat a pinworm infection?

A

Albendazole (Rx) or pyrantel pamoate (OTC)

must treat everyone in the house

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How do you transmit a tapeworm infection?

A

Eating raw/undercooked beef or pork - larva transmission

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the S/S of a tapeworm infection?

A

Abdominal pain, loss of appetite, weight loss, upset stomach

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Can you treat tape worms with OTC meds?

A

No, only RX

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the signs of neurocysticercosis (extension of tapeworm)?

A

Infect muscles, brain, eyes causing cysts that show up on MRI or CT scan.
Seizures and headaches are most common CNS sx.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How do you treat neurocysticercosis?

A

Praziquantel or albendenzole +/- steroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How do you get infected with a guinea worm?

A

Ingestion of contaminated drinking water by larvae. Larvae gestate in abdomen for ~12 months.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are S/S of guinea worm infection?

A

Mature worms form blisters in skin, typically hands and feet.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How do you treat guinea worm infection?

A

No medical treatment.

Pul worm out thru skin.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What infections are you most likely to get in a tropical or subtropical area from walking barefoot?

A

Hookworm

Strongyloidiasis (SE united states too)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the major concern for someone who has a strongyloidiasis infection?

A

Hyperinfection from “autoinfection” in someone who is immunosuppressed.
infection disseminates all over the body.

17
Q

What antihelminthic is considered broad spectrum - covering roundworm, whip worm, hookworm, neurocysticercosis?
How does it work?

A

Albendazole

Paralyzes the parasite

18
Q

How must you administer albendazole?

A

Take with a fatty meal

may crush or chew

19
Q

What is the drug of choice for River Blindness, (Black Fly from Africa), strongyloidiasis?

A

Ivermectin

20
Q

What are the weird side effects of Ivermectin?

How do you administer it?

A

Mazzotti-type reaction - rash, fever, itching
Eye reactions
On empty stomach

21
Q

What is an OTC option for treating pinworms, roundworms, hookworms?

A

Pyrantel pamoate