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GIT Pharmacology > Antihelminthic Drugs > Flashcards

Antihelminthic Drugs Flashcards

1
Q

Drugs against nematode (r.worms)

A

Albendazole
Diethylcarbamazine
Ivermectin
Mebendazole
Pyrantel pamoate

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2
Q

Drugs against trematodes (flukes)

A

Bithionol
Metrifonate
Oxamniquine
Praziquantel

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3
Q

Drugs against cestodes (tapeworms)

A

Albendazole
Mebendazole
Niclosamide
Praziquantel

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4
Q

Albendazole drug of choice for

A

ascariasis, hookworm, pinworm and whipworm infections

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5
Q

Albendazole toxicity

A

reversible leukopenia
alopecia
LFTs elevated

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6
Q

Diethylcarbamazine drug of choice for

A

filariasis caused by wucheria bancrofti & brugia malayi and for eye worm disease (loa-loa)

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7
Q

Diethylcarbamazine toxicity

A

headache
malaise
anorexia
fever, rashes, ocular damage, joint/muscle pain in filariasis
hypotension, pyrexia, respiratory distress, prostration in onchocerciasis

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8
Q

MoA of Diethylcarbamazine

A

immobilizes microfilariae

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9
Q

MoA of Ivermectin

A

intensifies GABA mediated neurotransmission in nematodes and causes its immobilization

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10
Q

Ivermectin drug of choice for

A

onchocerciasis
cutaneous larva migrans
strongyloidiasis

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11
Q

Toxicity of ivermectin

A

fever
rashes
pruritis
tachycardia
hypotension
muscle and joint pain

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12
Q

Mebendazole drug of choice for

A

ascariasis
pinworm and whipworm infections

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13
Q

drug interactions for mebendazole

A

plasma levels decreased by carbamazepine or phenytoin and increased by cimetidine

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14
Q

mebendazole toxicity

A

GI irritation
granulocytopenia and alopecia at higher doses

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15
Q

Pyrantel pamoate moa

A

stimulates nicotinic receptors of nematodes which leads to depolarization induced paralysis
- kills adult worm in the colon but not the eggs

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16
Q

schistosoma

A

blood flukes

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17
Q

clonorchis sinensis

A

liver fluke

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18
Q

paragonimus westermani

A

lung fluke

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19
Q

Praziquantel drug of choice for

A

schistosomiasis
clonorchiaisis
paragonimiasis
intestinal flukes

20
Q

toxicity of praziquantel

A

headache
dizziness
drowsiness
malaise

21
Q

Bithionol drug of choice for

A

co-drug of choice (with triclabendazole) for fascioliasis

22
Q

taenia saginata

A

beef tapeworm

23
Q

taenia solium

A

pork tapeworm

24
Q

diphyllobothrium latum

A

fish tapeworm

25
Q

echinococcus granulosus

A

dog tapeworm

26
Q

niclosamide drug of choice for

A

alternate drug for praziquantel

27
Q

drug for Ascaris lumbricoides (roundworm)

A

Albendazole or mebendazole or pyrantel pamoate

28
Q

drug for Necator americanus and Ancylostoma duodenale (hookworm)

A

Pyrantel pamoate or albendazole or mebendazole

29
Q

drug for Trichuris trichiura (whipworm)

A

Albendazole or mebendazole

30
Q

drug for Strongyloides stercoralis (threadworm)

A

Ivermectin

31
Q

drug for Enterobius vermicularis (pinworm)

A

Mebendazole or pyrantel pamoate

32
Q

drug for Trichinella spiralis (trichinosis)

A

Mebendazole (+/– corticosteroids)

33
Q

drug for Cutaneous larva migrans

A

Albendazole or ivermectin

34
Q

drug for Wuchereria bancrofti and Brugia malayi (filariasis)

A

Diethylcarbamazine

35
Q

drug for Onchocerca volvulus (onchocerciasis)

A

Ivermectin

36
Q

drug for Schistosoma haematobium

A

Praziquantel

37
Q

drug for Schistosoma mansoni

A

Praziquantel

38
Q

drug for Schistosoma japonicum

A

Praziquantel

39
Q

drug for Paragonimus westermani

A

Praziquantel

40
Q

drug for Fasciola hepatica (sheep liver fluke)

A

Bithional or triclabendazole

41
Q

drug for Fasciolopsis buski (large intestinal fluke)

A

Praziquantel or niclosamide

42
Q

drug for Taenia saginata (beef tapeworm)

A

Praziquantel or niclosamide

43
Q

drug for Taenia solium (pork tapeworm)

A

Praziquantel or niclosamide

44
Q

drug for Cysticercosis (pork tapeworm larval stage)

A

Albendazole

45
Q

drug for Diphyllobothrium latum (fish tapeworm)

A

Praziquantel or niclosamide

GIT Pharmacology (6 decks)

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