Antigen receptors and lymphocyte development

Question 0

Where is the gene for encoding the heavy chain of antibodies located?

Answer 0

Chromosome 14

Question 1

Immature T cell expressing CD4, CD8 and CD3

Answer 1

is double positive

CD3 is a molecule that stabilizes TCR

Question 2

Immunogen

Answer 2

molecule that elicits an immune response by binding a TCR or an antibody

Question 3

what type of immunogen is the strongest? weakest?

Answer 3

Protein

Amino acids and Haptens - weakest/dont elicit a response

Question 4

FcRs are found on?

Answer 4

Phagocytes

Question 5

Preformed receptors

Answer 5

PRR and TLR
KAR and KIR on NK cells
CR - complement receptors
FcR on phagocytes

Question 6

Generated receptors

Answer 6

TCR

BCR

Question 7

KAR detect

Answer 7

stress related molecules
MICA
MICB

Question 8

Target cells present antigen to T cells on

Answer 8

MHC I

Question 9

KIRs detects

Answer 9

MHC I on nucleated cells in the body

Question 10

TCR is composed

Answer 10

alpha and beta chains
beta has a variable, diversity and joining regions
alpha only has variable and joining region

Question 11

Ig heavy components

Answer 11

variable, diversity and joining chains

Question 12

how many chances do you have to get the heavy chain right?

Answer 12

2

we have two chromosomes

Question 13

what chromosome are the light chains found on?

Answer 13

Chromosome 2

Question 14

how many chances do have for the light chain?

Answer 14

4 to make a functional immunoglobin
due to allelic exclusion

4 over 2 because light chain either composed from kappa and lambda chains

Question 15

For apoptosis after exhausting the light chain rearrangement, how many outcomes did that take?

Answer 15

5
1 successful heavy chain
4 failed light chains

Question 16

what is the difference between the H and kappa chain?

Answer 16

H chain contains diversity regions

both have variable, joining and constant regions

Question 17

what chromosome is the lambda chain on?

Answer 17

chromosome 22

Question 18

For immunoglobins, what chain contains the diversity regions?

Answer 18

mu chain

or heavy chain

Question 19

what activates immune T cells?

Answer 19

Antigen presentation via MHCs

Question 20

what is unique about a gamma/delta T cell?

Answer 20

not MHC restricted
very small portion of population
usually found in Gut
also called Intraepithelial lymphocytes

Question 21

At what point in T cell maturation is the DN cell picking between a/b and y/d chains?

Answer 21

As a DN2

Question 22

TCR beta/delta chains are analogous to what in immunoglobins?

Answer 22

the heavy chain

Question 23

At what stage are Tcells committed to alpha/beta lineage?

Answer 23

DN3

Question 24

At what stage in T cell development is beta chain rearrangement occuring?

Answer 24

DN3

Question 25

When does alpha chain rearrangement occur for T cells?

Answer 25

when they are Double positive

Question 26

Lymphoproliferative syndrome due to

Answer 26

defective FasL in B and T cell interactions

Question 27

B cell needs two somatic changes

Answer 27

rearrange heavy cell - b cell precursor | IgM displayed on immature B cell

Question 28

B cells mature in

Answer 28

Lymph nodes

Question 29

Immature B cells display

Answer 29

IgM

Question 30

Mature B cells display

Answer 30

IgM and IgD?

Question 31

What region determines the type of antigens?

Answer 31

Constant region

Question 32

During development what C regions are encountered first when making Immunoglobins?

Answer 32

C mu region

Question 33

Class switching

Answer 33

``` generates Igs other then IgM depends on interleukins secreted from T cells to induce class switching ```

Question 34

what determines if a rearrangement is successful?

Answer 34

if the rearrangement produces useless or self reactive portions then it is terminated