Antigen Processing

Question 1

What 2 things are ubquintated for proteosome destruction?

Answer 1

dRip (defective ribosomal proteins) viral protein

Question 2

How do Dendritic cells take up antigen?

Answer 2

Endo and phagocytosis

Question 2

What type of proteosome is used to breakdown viral proteins?

Answer 2

20s

Question 3

Describe the invariant chain and its purpose

Answer 3

Also called CD 74 it binds the alpha and beta chains of the inactive MHC-II and a portion of the invarient chain (called clip) blocks the antigen site until HLA-DM binds peptide and kicks clip out.

Question 4

What is the off switch for the inactivation of T cells

Answer 4

CTLA-4

Question 5

Which immune cell consititively expressed MHC II and B-7

Answer 5

Dendritic Cells

Question 6

Dendritic cells have the ability to activate which types of T cells?

Answer 6

naive effectory memory cells

Question 7

Describe a MHC Class I Deficiency

Answer 7

Def CD8+ normal CD4+ increased NK

Question 9

Diagnosis for a patient with a decreased CD4+ expression who can still respond to non-specific antigens. Also what is the treament

Answer 9

MHC Class II Deficiency Stem Cell Transplant

Question 10

Which immune cells have both PRR and T cell activation?

Answer 10

Macrophages