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Antimicrobials > Antifungals > Flashcards

Antifungals Flashcards

1
Q

Antifungal Classes

A

Polyenes, Allylamine, Azoles, Echinocandins

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2
Q

Polyene Action

A

Makes pores in ergosterol cell membrane

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3
Q

Polyene Examples

A

Amphotericin B, Nystatin

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4
Q

Amb Spectrum

A

Systemic Fungal Infection (IV)

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5
Q

AmB SE’s

A

Allergies, Nephrotoxicity,

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6
Q

Nystatin Spectrum

A

Superficial Fungal Infection (topically)

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7
Q

Allylamine Action

A

Inhibit ergosterol synth

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8
Q

Allylamine Example

A

Terbinafine

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9
Q

Terbinafine Spectrum

A

Dermatophyte Infection (broad) (topical & oral)

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10
Q

Terbinafine SE’s

A

Hepatotoxicity

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11
Q

Azole Types

A

Imidazole + Triazole

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12
Q

Azole Action

A

Inhibit ergosterol synth

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13
Q

Azole SE’s

A

Imidazole= Toxic (rarely used) Triazole= Less toxic +Hepatotoxicity + CP450 interactions

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14
Q

Imidazole Example

A

Clotrimazole

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15
Q

Triazole Examples

A

Fluclonazole + Itraconazole +Voriconazole + Posaconazole + Isavuconazole

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16
Q

Fluconazole Spectrum

17
Q

Itra/vori-conazole Spectrum

A

Yeasts + Aspergillus

18
Q

Posa/isavu-conazole Spectrum

A

Yeasts +Aspergillus + Moulds

19
Q

Imidazole use

A

Superfical topical dermatophyte infections

20
Q

Triazole use

A

Oral/IV systemic infections (candidiasis+fluclonazole)

21
Q

Echinocandin Action

A

Beta 1-3 Glucan synthase inhib

22
Q

Echinocandin Examples

A

Anidulafungin

23
Q

Echinocandin Spectrum

A

Aspergillus + Candida (not all moulds) (IV)

24
Q

Echinocandin SE’s

25
Q

5-Flourocytosine facts

A

Cytosine analogue, inhibit RNA/Protein/DNA synth, Yeasts only, BM surpression, Cryptococcal meningitis (w/ AmB)

26
Q

Griseofulvin facts

A

Inhibit mitosis, Dermatophyte Infections, children

Antimicrobials (4 decks)

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