Antifungal Lecture Questions Flashcards
What method of drug delivery would be better for minor fungal toenail infection: oral or topical?
topical. want to localize treatment
Why is normal saline infused in a patient receiving amphotericin B to?
diminish renal damage
Which of the following antifungals is most closely related to anticancer drug 5-gluoroucil?
amphotericin, flucytosine, fluconazole, caspofungin, griseofulvin
flucytosine.
5-fluorouracil must be metabolized to reach active form. Resistance can develop if cancer cell changes its metabolism and never activates it.
Which of the folloiwng antifungals would most likely produe bone marrow suppression as an adverse effect?
amphotericin, itraconazole, posaconazole, flucytosine, voriconazole
flucytosine - will target proliferating cell populations. Can cause bone marrow suppression
Blurring and changes in color vision or brighness are most commonly associated with the use of: itraconazole, posaconazole, flucoanazole, ketoconazole, voriconazole?
voriconazole. - cause this adverse efffect
What is the mechanism of Amphotericin B?
it binds to ergosterol and alters the membrane permeability
Which other organ system is also likely to be adversely affected by flucytosine?
renal, cns, cv, GI, hepatic
GI and hepatic
Which fungal drug is most commonly known to cause renal toxicity?
amphotericin
The imidazole drug, ketoconazole, is distinguished form the triazoles, like flucoonazole, by its:
higher aqueous solubility, longer half-life, greater reanl elimination, lower selectivity for fungal CYPs, ability to be administered IV
Lower selectivity for fungal CYPs.
Available as both topic and oral administration.
Which of the following antifungals possesses the broadest specturm of antifungal activity? itraconazole, naftifine, amphotericin B, caspofungin, griseofulvin?
amphotericin
Amphotericin liposomal formulations provide for? reduced dose requirements, diminished renal toxicity, reduced cost, absence of infusional toxicity, greater oral bioavailability, reduced half-life
diminished renal toxicity
clincial use of which of the following antifungals would most likely give rise to gynecomastia and impotence in males?
ketoconazole. has different CYP activity, but inhibits mammalian CYP activity, speficallly the one that produces testosterone - causes impotence and lower sperm count (gynecomastia). This is usually bad, but can also be used to treat prostate cancer.
Which of the following inhibits the production of ergosterol thorugh a non-CYP mediated event? flucytosine, caspofungin, nystatin, posaconazole, terbinafine?
terbinafine. Inhibits upstream of the CYP inhibition of the azole drugs.
