Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PHARMA > ANTIFUNGAL DRUGS FOR CUTAENOUS MYCOTIC INFECTION > Flashcards

ANTIFUNGAL DRUGS FOR CUTAENOUS MYCOTIC INFECTION Flashcards

1
Q

What are the three different fungi that causes majority if cutaneous infection?

A
  • Trichophyton
  • Microsporum
  • Epidermorphyton
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

It is a mold-like fungi that causes cutaneous infection

A

dermatophytes or tinea

Most common site is tinea pedis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the 1st drug of choice for dermatophyte?

A

Squalene epoxidase inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what are the 3 squalene epoxidase inhibitor?

A
  • Terbinafine
  • Naftifine
  • Butenafine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MOA of Squalene epoxidase inhibitors

A

Inhibition of the enzyme squalene epoxidase that converts squalene to squalene oxide thereby blocking production of ergosterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the drug of choice for treating dermatophyte oncychomycoses (fungal infections of nails)?

A

Terbinafine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

spectrum of terbinafine

A
  • effective against Trichophyton than either itraconazole or griseofulvin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Pharmacokinetics of terbinafine

A
  • prolong therepy (3 months)
  • Oral administration may be used for tinea capitis (infection in scalp)

-Topical terbinafine - tinea pedis, tinea corporis (ringworm), tinea cruris (“jock itch) and tinea versicolor dure to malassezia furfur

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Adverse effect of terbinafine

A
  • diarrhea
  • dyspepsia
  • nausesa
  • headache
  • rash
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what drugs is allylamines?

A
  • terbinafine
  • NAftifine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Inhibition of the enzyme squalene epoxidase that converts squalene to squalene oxide

A

They are extensively metabolized by P450s, very greasy so low solubility leading to low bioavailability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which CYP enzyme does terbinafine inhibit

A

CYP2D6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Oral use for terbinafine

A

Nail infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which drugs are non-allylamines squalene epoxidase inhibitors

A

Butenafine and Tolnaftate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

naftifine administration

A
  • cream and gel for 2 to 4 weeks

Target:
- tinea corporis, tinea cruris, and tinea pedis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Butenafine spectrum

A

Broader spectrum than tolnaftate and allylamines.

  • Trichophyton rubrum, Epidermophyton and Malassezia
17
Q

A drug that causes disruption of the mitotic spindle and inhibition of fungal mitosis

A

Griseofulvin

18
Q

griseofulvin is replaced by? in treating onychomycosis?

A

terbinafine

because griseofulvin requires a long duration (6 to 12 weeks)

19
Q

contraindication of griseofulvin

A

pregancy and patients with porphyria

20
Q

what three species cause these mycoses?

A

epidermophyton spp, trichophyton spp, microsporum spp

21
Q

it is a polyene antifungal

A

Nystatin

22
Q

what antifungal drug resembles amphotericin B

A

Nystatin

23
Q

spectrum of nystatin

A

cutaneous and oral candida infections

24
Q

Pharmacokinetics of nystatin

A

administered orally,

Treatment of
oropharyngeal candidiasis, intravaginally for vulvovaginal candidiasis and topically for cutaneous candidaiasis

25
Q

azole derivatives that used to treat dermatophytes

A

Imidazole

26
Q

spectrum of imadazole

A

tinea corporis
- tinea cruris
- tinea pedis
- oropharyngeal and vulvovaginal candidiasis

27
Q

class of imazoles used in cutaneous

A

Clotrimazole - as troche (lozenge)
Miconazole - buccal tablet for thrush
ORal Ketoconazole - treat fungus (yeast) but rearely used because of severe side effect

28
Q

A tropical antifungal triazole agent approved for the treatment of toenail onychomycosis caused by Ttriophyton rumbrum and Trichophyton mentagrophytes

A

Efinaconazole

29
Q

spectrum of efinaconazole

A

active against Candida albicans

30
Q

a pyridine antimycotic antifungal drugs

A

Ciclopirox

31
Q

MOA cicloprox

A

inhibits the transport of essential elements in the fungal cell, disrupting the synthesis of DNA, RNA, and proteins

32
Q

Ciclopirox shampoo is used for?

A

seborrheic dermatitis

33
Q

An antifungal drugs that inhibits aminoacyl-transfer ribonucleic acid synthesase, preventing fungal syntehsis

A

Tavaborole

34
Q

A topical thiocarbamate antifungal drugs that distorts the hyphae and stunts myceil growht in susceptible fungi

A

Tolnaftate

PHARMA (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions