Antifibrinolytic drugs Flashcards
1
Q
Give two examples of antifibrinolytic drugs
A
Tranexamic acid
Aprotinin
2
Q
what is the mechanism of action of Tranexamic acid
A
•Inhibits plasminogen activation
3
Q
How is Tranexamic acid administrated
A
•Oral or IV administration
4
Q
What is the clinical use of Tranexamic acid
A
•When there is increased risk of bleeding (dental extraction / prostatectomy)
5
Q
What are the side effects of Tranexamic acid
A
- Nausia
* Vomitting
6
Q
What is the mechanism of action of Aprotinin
A
•Proteolytic enzyme inhibitor of plasmin / kallikrein
7
Q
How is Aprotinin administrated
A
•Slow IV
8
Q
What is the clinical use of Aprotinin
A
•In patients with high risk of blood loss during and after open heart surgery
