Antieplieptic Drugs

Question 1

Drugs that block voltage gated sodium channels

Answer 1

Carbamazepine
Oxcarbezapine
Lamotrigine
Phenytoin
Valproic acid
Topiramate
Zonisamide

Question 2

Drugs that block calcium channels

Answer 2

Lamotrigine
Topiramate
Zonisamide
Valproic acid

Question 3

Drug that blocks the AMDA receptors

Answer 3

Topiramate

Question 4

Which drugs block HVA Calcium channel and which block t-type calcium channels

Answer 4

HVA Ca channels
Lamotrigine
Topiramate

T-type calcium channels
Valproic acid
Zonisamide

Question 5

Drugs that INTERACT with high voltage activated calcium channels (HVA )

Answer 5

Gabapentin
Pregablin
- they bind to to the sub unit on the HVA calcium channel called alpha-2-delta-1

Question 6

Drug that blocks HVA calcium channel blockers by binding to SV2A protein found in vesicles that contain glutamate

Answer 6

Levitrecetam

Question 7

Blocks NMDA receptor and inhibits excitatory neurotransmission

Answer 7

Felbomate

Question 8

Drugs that act on the GABA system and how

Answer 8

Benzodiazepine
Barbiturates
- they bind to GABA-A receptor and prolong the opening of channel allowing greater influx of negatively charged chloride ions into neuron

Question 9

Drug that selectively inhibits GABA transporter by blocking GABA reuptake and allowing more GABA available for receptor binding on post synaptic neuron

Answer 9

Tiagabine

Question 10

Irreversibly inhibits GABA-T thus increasing concentration of GABA in the brain

Answer 10

Vigabatrin

Question 11

Drugs that cause hyponatraemia

Answer 11

Carbamazepine
Oxcarbezapine

Question 12

Drugs that cause visual loss

Answer 12

Vigabatin

Question 13

Drugs that cause double vision

Answer 13

Lamotrigine
Phenytoin

Question 14

Drugs that cause cognitive issues

Answer 14

Topiramate
Zonisamide

Question 15

Drugs that cause weight gain

Answer 15

Valproic acid
Gabapentin
Pregablin

Question 16

Drugs that cause liver toxicity

Answer 16

Valproic acid
Felbomate